News & Events

Spot our Highlights & News

Opening of our new application labs & office in SD

It’s official: last night we celebrated the opening of our San Diego office.

On December 7th, 2017 we welcomed invited guests to our new space for a good old-fashioned office warming party. Employees, customers & friends came together to celebrate the new location enjoying tasty food, good drinks & the joyous atmosphere.

Located in the Miramar neighbourhood of San Diego, CA, the new office is a bright airy space with lots of (technical) details to explore.
Stop by – we are very much looking forward to welcoming you at our new application labs & office space!

Dynamic Biosensors Inc.

9705 Carroll Centre Road, Suite 100
San Diego, CA 92126, USA

Launch of switchSENSE® MP3 multi-purpose chip
with 3 nanolever densities. Ligand density control made easy.

Trying to decipher complex binding interactions?
Ligand density control is the key.

Introducing the switchSENSE® multi-purpose chip MP3 with its three predefined ligand surface densities.
Makes it easy to experiment with different and ultra-low densities, and ensures quick experimental success even for challenging interactants.

  • Ready-to-use biosensors prepared with 3 different nanolever (ligand) densities.
  • Compatible with Invisibility Cloaking and Electrical Desorption for the user-controlled adjustment of ligand densities.
  • Fluorescence-based switchSENSE® technology for reliable analyte binding detection.
    Compatible with dynamic and static measurement modes.
  • 2D surface attachment (no matrix effects).
  • Sequences are compatible with standard switchSENSE® Multi-Purpose-Chips (MPC).

You find more information here.


 

Scripps Researchers utilize the Versatility of Dynamic Biosensors’ Smart Molecular Interaction Technology for Biophysical Characterizations

News Release

LA JOLLA, CA – As part of a six-month collaboration, Dynamic Biosensors Inc. installed in August 2017 one of their dual-color DRX2 analyzer instruments for molecular interaction analysis and biophysical characterization in Prof. Jeffery W. Kelly’s lab. Using the patented switchSENSE® technology, the DRX2 system provides smart solutions for binding kinetics measurements, the analysis of absolute protein sizes and aggregate formation, protein conformational changes and melting behavior, as well as  bispecific antibody affinity and avidity properties. Over the course of the past two months, this collaboration has grown and to include 14 Scripps scientists – from six research groups across three different departments – who utilize the versatility of the technology for their diverse research topics.

Read more

Of the first to use the technology was senior postdoctoral research associate, Dr. Gareth Morgan, from the Kelly Group. Dr. Morgan used the switchSENSE® technology, particularly the unique protein sizing analysis, to assess the unfolding and refolding processes upon melting or urea denaturation of light chain, known to play a crucial role in neurodegenerative diseases. The determination of the absolute hydrodynamic diameter at distinct time intervals during the target protein’s unfolding process revealed novel insights into the refolding kinetics and structural properties of the target.

Prof. Kelly and Dr. Morgan say “when we try to understand complex biological systems, teasing apart individual processes is essential. If we try to measure protein misfolding in bulk solution, we often see a protein subpopulation that aggregates, which obscures the most interesting molecular changes when studying aggregation disease-associated proteins. The switchSENSE® technology allows us to look at protein molecules that are isolated from each other, so that we can be more certain of what we’re actually measuring employing individual proteins. What is really powerful is that these measurements provide information that has distinct attributes, relative to what we have been able to measure previously. For example, this approach enables us to ascertain how a protein changes its shape when it unfolds and refolds, which is an important factor in determining why some proteins adopt a misfolded subpopulation, leading to aggregation and pathology, while others do not. The robust and accessible surface chemistry of the DRX2 instrument meant that we could efficiently adapt our experiments to the switchSENSE® system. We are encouraged by the preliminary results, that should provide novel insights into the misfolding and aggregation processes contributing to neurodegenerative diseases.”

For the duration of this collaboration, scientists from Dynamic Biosensors will closely support Scripps researchers by training them to use the DRX2 system and enabling them to independently design and set up their diverse experiments.

If you are interested in using the DRX2 analyzer platform for your research, or if you would like further information on the switchSENSE® technology and its applicability to your project goals, please contact Kenneth Dickerson (dickerson@dynamic-biosensors.com) or Assoc. Prof. Evan Powers (epowers@scripps.edu), the DRX2 responsible at Scripps.

About The Scripps Research Institute

The Scripps Research Institute (TSRI) is one of the world’s largest independent, not-for-profit organizations focusing on research in the biomedical sciences. TSRI is internationally recognized for its contributions to science and health, including its role in laying the foundation for new treatments for cancer, rheumatoid arthritis, hemophilia, and other diseases. An institution that evolved from the Scripps Metabolic Clinic founded by philanthropist Ellen Browning Scripps in 1924, the institute now employs more than 2,500 people on its campuses in La Jolla, CA, and Jupiter, FL, where its renowned scientists—including two Nobel laureates and 20 members of the National Academies of Science, Engineering or Medicine—work toward their next discoveries. The institute’s graduate program, which awards PhD degrees in biology and chemistry, ranks among the top ten of its kind in the nation. In October 2016, TSRI announced a strategic affiliation with the California Institute for Biomedical Research (Calibr), representing a renewed commitment to the discovery and development of new medicines to address unmet medical needs.

For more information, see www.scripps.edu

 

About Dynamic Biosensors

Dynamic Biosensors is a provider of instruments, consumables, and services in the field of analytical systems for the characterization of biomolecules and molecular interactions. The company commercializes switchSENSE® technology, a groundbreaking platform technology for the analysis of biomolecules with applications in R&D and drug development. The switchSENSE® technology is protected worldwide and only available through Dynamic Biosensors. The development of the technology has been partially funded by a GO-Bio project grant from the German Federal Ministry of Education and Research (BMBF). The company is headquartered in the south of Munich, Germany and runs offices in the United States, the United Kingdom, in France, Japan and Singapore.

For more information, see www.dynamic-biosensors.com

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For information:
Katharina Lang
Marketing & Communications Manager

Tel: +49 (0)89 / 89 74 544 – 21
lang@dynamic-biosensors.com

Meet dynamicBIOSENSORS

17th Annual PepTalk: The Protein Science Week

From January 08, 2018 until January 12, 2018

At Hilton San Diego Bayfront / San Diego, California / United States

Meet Dynamic Biosensors at the 17th Annual PepTalk: The Protein Science Week

PepTalk: The Protein Science Week is one of the largest annual gatherings of protein science researchers in the world. Now, in its 17th year, PepTalk attracts nearly 1,300 experts from academia, biotech and pharma who come together for one week of intensive learning and networking to discover new opportunities, apply alternative solutions, and develop promising partnerships.

This event covers a wide spectrum of applied protein sciences with emphasis on upstream R&D engineering to downstream biologics production. And, whether you’re a world-renowned researcher or a current graduate student, PepTalk has something to offer:

Conference Programs feature keynote presentations, case studies and new unpublished data from top influential leaders in academia and industry.

Training Seminars (1.5 days) populate more of the event, combining the depth of a short course and length of a conference track across an even broader range of topics, allowing you to enhance your knowledge and gain insight and perspective even more fruitfully than before.

Dinner Short Courses (3 hours) offer a unique, intimate setting to delve into a particular topic. Each course provides a great introduction for those who are new to a discipline or a helpful refresher for those who want to brush up on their knowledge or expand their horizons.

Student Fellowships grant those entering the industry an opportunity to present their latest research and receive critical feedback for development and collaboration.

Exhibit Hall provides face-to-face networking with Technology & Service Providers ready to share their latest products and services.

During this event, Dynamic Biosensors will present its award-winning switchSENSE® technology for molecular interaction analysis & biophysical protein characterization.


SLAS 2018 International Conference & Exhibition

From February 03, 2018 until February 07, 2018

At San Diego Convention Center / San Diego, California / United States

Meet Dynamic Biosensors at SLAS 2018 International Conference & Exhibition

Since its founding in 2010, SLAS has provided valuable education and information to the exclusive community of life sciences professionals that work at the intersection of discovery and technology. Helping innovative researchers and engineers pioneer new scientific horizons by leveraging the power of technology has been a hallmark of the Society since day one.

And just as the life sciences are evolving at an accelerated pace, SLAS adapts to deliver the insights, access to technology and peer connection opportunities to ensure our members remain well-informed and wellconnected to achieve breakthrough research.

During this event, Dynamic Biosensors will present its award-winning switchSENSE® technology for molecular interaction analysis & biophysical protein characterization.


62nd Biophysical Society Annual Meeting

From February 17, 2018 until February 21, 2018

At San Francisco, California / United States

Meet Dynamic Biosensors at the 62nd Biophysical Society Annual Meeting

As science becomes increasingly interdisciplinary, the Biophysical Society Annual Meeting continues its long-held reputation for bringing together leading scientists from the all over the world who work at the interface of the life, physical, and computational sciences.

The dynamic five-day Meeting provides attendees with opportunities to share their latest unpublished findings and learn the newest emerging techniques and applications.

Despite its nearly 6,500 attendees, the Meeting is noted for maintaining its “small meeting” feel beginning with the Saturday subgroup symposia, which allow attendees to meet within their scientific communities. It is also known for its vitality, demonstrated by the over 900 highly interactive daily poster presentations, the more than 500 speakers selected from submitted abstracts, the many career development programs for those working in academia, industry, and agencies throughout the world, and its advocacy and education programs.

During this annual meeting, Dynamic Biosensors will present its award-winning switchSENSE® technology for molecular interaction analysis & biophysical protein characterization.