heliOS Software

Download 1.6.1

We are pleased to announce that our latest 1.6.1 release of heliOS is ready for you to download. It includes new features, enhancements and bug fixes. The latest heliOS version comes together with an improved set of heliOS methods and a powerful firmware update (4.229.3.1455).

heliOS

version 1.6.1 (188 MB)

heliOS Methods

version 1.6 (1.3 MB)

heliX Firmware

version 4.229.3.1455 (1.4 GB)

heliX Quick Start Guide

version 3.1 (3.49MB)

Note: Before running a new heliOS version, a firmware update of your heliX device is necessary.

SYSTEM REQUIREMENTS
Supported Operating System I Windows 10

heliOS requires the .NET 5 Desktop Runtime. 
heliOS requires access to a postgreSQL database.

 

→ see install instructions

We are pleased to announce that our latest 1.6.1 release of heliOS is ready for you to download. It includes new features, enhancements and bug fixes. The latest heliOS version comes together with an improved set of heliOS methods and a powerful firmware update (4.229.3.1455). 

Here is a list of the key features we have introduced or improved: 

  • We have introduced a timeline view in the experiment section. The timeline is a new user interface that illustrates the duration, the start and end points as well as the content of all steps of an experiment. Open your finished experiment, click on Timeline and get an overview about all measurements, raw data, assay elements, fluidic steps and other events.
  • Another new user interface that has been introduced is the chip tray view. It illustrates the loading status of the chip tray including a tabular view of the chip information, the chip type and ID as well as a signal light display of the chip status.
  • Two new origami assays for conformational change scouting have been developed. One for His-tag captured proteins and the other one for conjugated proteins. Both assays come along with powerful analyses equipped with automatic data handling and referencing, conclusive result plots, QC plots and statistical tests.
  • The Clean & Sleep and Wake Up & Prime routines have been improved and simplified. Instead of manually changing the buffer bottles in between you can now load the device once, start the new single-step Clean & Sleep and leave the device alone. A one-click Wake Up & Prime lets the device be prepared for the next measurement in only 5 minutes.
  • The analysis section, especially the manual analysis, has been substantially improved in usability and performance, and has been extended by various new operations and functionalities.

Device and Maintenance

New single-step routines of clean & sleep and wake up & prime

Add chip information user interface

Methods

Improve handling of parameters in composed methods

Add ability to expose read-only parameters from composed methods

Assays

New origami assay for conformational change scouting of His-tag captured proteins

New origami assay for conformational change scouting of protein conjugates

Improve precision and visibility of run time estimation

Open used methods directly from your assay workflow

Add temperature control for all assays

Highlight advanced parameters when they are activated in an assay

Add ability to generalize custom assay parameters

Allow reordering of assay runs using drag and drop

Add ‘none’ as well plate configuration for autosampler

Add conversion factor for units in CSV data import

Enable export of custom assay parameter tables

Add autosampler export as Genedata Screener Compound Mapping Table

Experiments

Add experiment timeline view

View samples, ligands and concentrations in measurement table

Improve arrangement of experiment images

Analyses

New analyses for conformational change scouting assays

Add CSV export to parameter tables in automated analyses

Add division and real-time reference operations to manual analyses

Improve descriptions of analysis operations in manual analyses

Improve format of fit equations and results

Enable copy and paste of analysis scratchpad elements using Ctrl + C and Ctrl + V

Improve positioning of analysis elements when added to a manual analysis

Replace cryptic numbers with index numbers in operations requiring data selection

Enable adjustment of dynamic lag integration window in manual and automated analysis

Use measurement name as default name for measurement data sources in manual analyses

Add support for points with uncertainties in plots

Add digital line plot type

Simplify changing the format of plot elements

Improve CSV export of analysis data

Improve performance of assays with large number of runs

Improve script parsing and assay workflow performance

Speed up assay start by aggregating devices in the background

Improve import-export system of large files

Reduce RAM consumption

Fix trace selection not working consistently

Fix plot legends shown in reverse order

Fix crash when manually changing masking parameter

Fix rare error while loading assays

Fix sample not being available in live-observed measurements

Fix crash when trying to edit fit parameters

Fix error when opening composites

Fix font size of legends in exported plots

Fix metadata detection in interaction detection operation

Prevent crash when opening devices or experiment while the database connection is lost

Fix concurrency problem when resuming download

Fix time prediction of running experiments during live view

Fix crash when changing range parameters through plot interface

Fix rare issue preventing opening of older methods

Fix crash when recalculating automatic analyses after modifying plot properties

Fix rare crash when duplicating an assay

Fix composites sometimes not opening

Fix uncertain values not being displayed correctly in plot markers

Fix crash caused by different dialogs

Fix hit screening analysis not working if passivation solution was not ejected before first sample injection

Fix automated analysis not finishing for FT analysis

Prevent crash when failing to locate VLC player

Prevent error list from appearing below script editor if no errors were found

Fix crash when making an element in a composite optional twice

Fix temperature and chip parameters not working in composed methods

Fix warning messages not always appearing in focus

Fix manual fitting error being non-nan for fixed values

Fix fit of parameters failing if their bounds are setup with the minimum being larger than the maximum

Fix backward compatibility with limits-changed events

Fix scroll bar jump when pasting rows or importing a .csv file in a custom assay

Change fallback inflection point to 0.33 V

Fix error message when resuming download of an experiment

Fix export formats for plots

Fix context menu to create forked composite methods

Fix composite method corruption when replacing one or more elements

Fix potential crashes while masking points

Fix propagation of parameter descriptions in methods and assays

Fix rare crash in plots in live experiment page

Fix fit curve not being highlighted against raw data

Fix crashes when using slider based parameter value modification

Fix plot not reacting to mouse clicks after undocking

Fix parameters resetting in manual analyses generated from automated analyses

Prevent importing generalized parameters from CSV

Fix column delimiters in autosampler export for Genedata Screener

Fix crash when pasting same data source element twice into the same manual analysis

Fix device loader not working

Fix fit results being propagated through multiple analysis elements

Fix crash when opening ligand settings in kinetics assay

Fix elements not collapsing in manual analysis

Fix crash when opening manual analysis of automated analysis with many elements

Fix device UI sometimes updating during aggregations

Fix crash when changing name of reference operation without any associated data

Fix assays not being selectable in assay workflow

Fix error when trying to open some experiments

Fix images not being shown in new experiments

Fix imports of legacy files containing blank lines

Fix automated analysis details requiring multiple clicks on save button

Fix potential crash after leaving heliOS open while windows goes into sleep mode

Fix unblocked interactions with plots outside of manual analysis

Add scrollbar to script parameters

Fix issues with opening old analyses that had manually adapted fit parameters

In case you need help, please do not hesitate to contact our support team at support@dynamic-biosensors.com.

INSTALL INSTRUCTIONS

We recommend to always use the newest versions of heliOS and heliX firmware.
Please update first your heliX device with the latest firmware version before installing a new version of heliOS.

SYSTEM REQUIREMENTS

Supported Operating System I Windows 10

heliOS requires the .NET 5 Desktop Runtime. 
heliOS requires access to a postgreSQL database.

heliX FIRMWARE UPDATE

Note: The installation of a new heliX firmware version must be performed from a computer which is connected to the heliX device.

Note: Skip this step if you are only interested in updating the heliOS version on a computer which is not used to control the heliX device.

  1. Ensure that the heliX device is switched on and connected to the control PC (directly or via network).
  2. Download the above listed version of the heliX firmware. We recommend to always use the newest version.
  3. Run the EXE installer on the control PC and follow the setup steps. You can find the IP address of your heliX in heliOS under Devices.
    After approx. 10 minutes the heliX will be restarted and ready to use.

INSTALLATION OF heliOS

Note: If heliOS is installed for the first time on a computer you need to first install the .NET 5 Desktop Runtime (see Installation of Microsoft .NET 5) and a PostgreSQL database (see Installation and set up of postgreSQL database).

 

  1. Download the above listed version of heliOS. We recommend to always use the newest version.
  2. Run the MSI installer and follow the setup steps.
  3. The first time you open heliOS on a computer you need to enter your license key (Settings → License).
    Copy and paste the license key into the intended input field and confirm.
  4. In addition to 3, the first time you are using heliOS you need to enter your database access data (Settings → Database).
  5. Now heliOS is ready to use and can, for example, be connected to your heliX device.

IMPORT OF heliOS METHODS

  1. Download the above listed heliOS methods.
  2. Unzip the downloaded file once. The unzipped folder contains a range of zipped heliOS methods. Do not unzip these files.
  3. Open heliOS and go to “Methods”.
  4. Click on “Import” in the top menu and select one or several heliOS methods (ZIP files) from the unzipped folder.
  5. Click on “Open”. Now your data base is equipped with the newest heliOS methods.

INSTALLATION OF MICROSOFT .NET 5

Note: heliOS requires the .NET 5 Desktop Runtime on your Windows operating system. If already installed you can skip this step.

 

  1. Download the .Net 5 Desktop Runtime from the link below. Select a version under “Run desktop apps” that matches the architecture of your Windows OS, either 32-bit (x86) or 64-bit (x64). https://dotnet.microsoft.com/download/dotnet/current/runtime
  2. Run the EXE installer and follow the setup steps.
  3. After the installation process has finished you are ready to install heliOS.

INSTALLATION AND SET UP OF A postgreSQL DATABASE

Note: heliOS requires a postgreSQL database either on a server in your local network or on your Windows operating system. If you do not have access to a network-based postgreSQL database you need to install one on your local computer. If already installed you can skip this step.

  1. Download postgreSQL from the link below. Select version 12.8 for Windows x86-64.
    https://www.enterprisedb.com/downloads/postgres-postgresql-downloads
  2. Run the EXE installer and follow the setup steps. A detailed installation guide can be found here: https://www.enterprisedb.com/docs/supported-open-source/postgresql/installer/02_installing_postgresql_with_the_graphical_installation_wizard/01_invoking_the_graphical_installer/
    If you need help with setting up the postgrSQL database please ask your system administrator or contact our support team at support@dynamic-biosensors.com.
  3. After the installation process has finished you are ready to install heliOS.

In case you need help, please do not hesitate to contact our support team at support@dynamic-biosensors.com.

Questions?
Contact Us

Our support team is happy to help. 

support@dynamic-biosensors.com

+49 89 89 74 544-0

Lochhamer Str. 15, 82152 Martinsried/Planegg, Germany

M-F: 8am-5pm, S-S: Closed