His-tagged proteins 
Conjugation Kit

Site-specific covalent conjugation and purification
of His-tagged proteins to DNA

With Dynamic Biosensors´ new site-specific labelling kits His-tagged proteins can be covalently conjugated to DNA in an orientated way with high efficiency.

A comparison of reaction yields from a conjugation of protein A and a 48mer DNA  with (right) and without (left) our proprietary guiding DNA method demonstrates not only more site selective conjugation using this method, but also a 50% higher relative yield.

Figure | Comparison of a reaction mixture of 50 µg protein A  with 48mer DNA without addition of Guiding DNA (left) and with addition of Guiding DNA (right).

PURE PROTEIN-DNA CONJUGATES

Well-defined protein-DNA conjugates are a very important tool for many bioanalytical applications including immunoassays, imaging techniques and surface bio-functionalization.

While for many of these applications conjugating a single DNA oligo to a specific location of the protein is critical, preparing pure and site-specific bioconjugates can still be a challenging process.

With Dynamic Biosensors´ proFIRE® labelling kits, covalent conjugation of His-tagged proteins to DNA can be carried out in a straightforward, site-selective way with higher efficiency using lower amounts of protein.

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🧬 LEARN about proFIRE® conjugation

Discover pure DNA-protein conjugates.

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