DRX Series

Fully automated switchSENSE® instruments are 96 well plates compatible and manufactured in Germany.

Wide ranging, deep data content on molecular interactions.
Binding Kinetics & Affinity I Protein Diameter

Conformational Change I Enzymatic Activity I Bispecific Binders & Avidity I Melting & Thermodynamics I Multimers & Aggregation

DRX Series

The DRX and DRX2 analyzers combine liquid handling, chip management and data capture for switchSENSE®measurements. Bespoke electronics manage the electrical actuation of biomolecules on the biochip and measurement of molecular dynamics via time-correlated single photon counting. The instrument also offers the proprietary electrical desorption methodology to adjust capture molecule densities.

Instruments are designed for walk-away operation with automated dilution series / liquid handling, temperature managed environments and stability for long overnight / multi-day studies.

Limit of detection 10 fM
Dissociation constant 50 fM – 1 mM
Association rate constant 1E3 – 1E8 /Ms
Dissociation rate constant 1E-6 – 1E0 /s
Hydrodynamic diameter accuracy of 0.1 nm
Temperature 8° – 75°C (chip), 10° – 40°C (autosampler)

DRXSeries

The double color DRX2 analyzer offers the simultaneous measurement of two different species of probes on the same biochip electrode.

Each sensor spot carries two nanolever sequences, one with a red tag, and one with a green. The instrument tracks the movement and position of the different nanolevers separately and simultaneously.

This technology offers novel methods of investigation including same-spot controls, dual binding modelling, ideal for bispecifics and Proof of Action experiments with two nanolevers to play with, using one nanolever for capture and the second for detection.

Have a look at our DRX2 Flyer

Limit of detection 10 fM
Dissociation constant 50 fM – 1 mM
Association rate constant 1E3 – 1E8 /Ms
Dissociation rate constant 1E-6 – 1E0 /s
Hydrodynamic diameter accuracy of 0.1 nm
Temperature 8° – 75°C (chip), 10° – 40°C (autosampler)

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