Brochure I October 20, 2021

Kinetics of multispecific binders:
Analysis of cooperative binding with switchSENSE®


switch
SENSE® FEATURES:

Straightforward sensor functionalization with two different antigens.

Variable ligand density to control interlinking when multivalent binders are measured.

Easily adjustable antigen surface ratios to mimic cell surface abundances.

Two-color detection to monitor each interaction individually.

Stable signals for long dissociations to measure slow avidity off-rates.

heliOS software with multi-phasic fitting algorithms to differentiate affinity from avidity.

 

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