Webinar I November 13, 2024

DISCOVER bispecific antibodies: generation, biophysical characterization and functional validation

This is the eighth episode of our second season of the DISCOVER MOLECULAR INTERACTIONS webinar series. Each month we will talk about cutting-edge drug discovery topics like bispecific antibodies, PROTACs or small molecules targeting RNA. We will show you how to characterize the respective molecular interactions in depth, how to create assays with remarkable biological similarity, low sample consumption, high versatility and exceptional ease-of-use. In this episode, we are discussing a promising therapeutic modality: bispecific antibodies. Prof. Kolmar is sharing his work on the generation of different bispecific formats using chicken immunization and FACS-assisted yeast surface display screenings. He showcases how surface-based biosensor technologies like switchSENSE® can be used to investigate the cooperativity between the two antibody arms, and how single-cell Interaction Cytometry offers unique insights into the binding capacity of bispecific binders by measuring their interaction directly on living cells.

If you are interested in another application, you can find all future episodes of this webinar series here
DISCOVER MOLECULAR INTERACTIONS webinar series