Introducing pure protein-DNA conjugates
proFIRE® is a unique system for protein-DNA conjugate preparation, delivering consistent and superior conjugate quality for your experiments.
smart biophysical analysis
for molecular interaction analysis.
Molecular Interaction Analysis
Unrivaled Information Content
- Binding Kinetics
- Binding Affinity
- Protein Diameter
- Conformational Change
- Nuclease & Polymerase Activity
- Bispecific Binders & Avidity
- Melting & Thermodynamics
- Multimers & Aggregation
Biophysical Analysis with Electro-Switchable Biosurfaces
Join us for this recorded webinar presentation to learn more about dynamicBIOSENSORS’ pioneering switchSENSE® sensor platform: an automated, fluorescence based biosensor chip technology that employs electrically actuated DNA nanolevers for biophysical and interaction analysis measurements!
This presentation covers the different measurement modes of our novel switchSENSE® technology, as well as its applications in biophysical analysis.
Paper in Angewandte Chemie
Tailored peptide phenyl esters block ClpXP proteolysis by an unusual breakdown into a heptamer‐hexamer assembly
04 March 2019
In a paper by Sieber and co-workers from the Technical University of Munich, switchSENSE® was used to study the interaction between the ClpPX protease subunits ClpX and ClpP, shedding light on the working mechanism of novel peptidic inhibitors.
Measurements of nanolever dynamics allowed, for the first time, the direct determination of the KD-value of the ClpX and ClpP interaction (KD = 19.5 μM). Covalent binding of inhibitors strengthens the ClpP-ClpX interaction (KD = 3.9 μM), while inhibiting proteolysis and impairing chaperone activity.
Paper in ACS Appl. Mater. Interfaces
25 December 2018
Together with scientists from the Technical University of Dresden, we used the switchSENSE® technology to study the behavior of large DNA-origami rods under different magnesium concentrations when exposed to an actuating potential.
The origami show a stable motion even in a magnesium free environment and their motion is independent of the charging time of the driving electrode. In addition, we found a correlation between the charge of origami and DNA rods with their sensitivity to the electric actuation.
Dr. Michael Schraeml, Head Protein and Enzyme Technologies
ROCHE DIAGNOSTICS GMBH
Products for High-Performance Analysis
switchSENSE® experiments are performed on reusable multi-electrode, multi-channels biochips.
Fully automated switchSENSE® instruments are 96-well plates compatible and manufactured in Germany.
Including coupling kits, starter packs, training & OQ kits, as well as buffers, solutions and other consumables.