DISCOVER 
MOLECULAR
INTERACTIONS

Kinetics – Affinity – Avidity
Conformational Changes
Thermodynamics

heliX®

switchSENSE® Technology
Molecular Interaction Analysis
Powered by
Electro-switchable Nanolevers
Unrivaled Information Content

read more >

  • Binding Kinetics
  • Binding Affinity
  • Protein Diameter
  • Conformational Change
  • Nuclease & Polymerase Activity
  • Bispecific Binders & Avidity
  • Melting & Thermodynamics
  • Multimers & Aggregation

Application Areas

heliX®
DISCOVER MOLECULAR INTERACTIONS

The dynamicBIOSENSORS team is excited to announce the launch of the heliX® line of biosensor instruments!

heliX® pushes the boundaries of what has been possible in biosensing to help you do more:

  • Analysis of binding kinetics and molecular conformations in one measurement.
  • Screening of conformational changes de novo by real-time conformation referencing.
  • Resolving the fastest kinetics with confidence using advanced microfluidics and 10 ms data collection, and taking advantage of improved signal stability for the characterization of high-affinity binders in long dissociation measurements.
  • Two-color single-photon counting fluorescence detection for femto-molar sensitivity and the in-depth analysis of bispecific binders.
  • Effortless sensor functionalization and advanced ligand density control with the new Adapter Chip.

heliX® is based on a modular technical design and features an automatic chip-loader in conjunction with a 384 well plate compatible autosampler, allowing you to scale-up throughput to thousands of samples per day.

In Focus

Paper in PNAS

An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2

switchSENSE® resolves the binding kinetics of the splicing factor U2AF2 to a target RNA sequence. Hyun-Seo Kang of Michael Sattler’s workgroup at the Technical University of Munich used switchSENSE® to confirm the regulatory function on RNA binding of an inter-domain linker in U2AF2 by measuring the association- and dissociation kinetics of the wildtype protein and of a mutant in which the regulatory linker region had been rendered inactive.

Paper in Scientific Reports

Preparation of single- and double-oligonucleotide antibody conjugates and their application for protein analytics

Well-defined antibody-DNA conjugates are a very important tool for many bioanalytical applications, including DNA-nanotechnology or proximity ligation assays (PLA). Researchers from the Helmholtz Center Munich used the proFIRE® technology to purify antibody-DNA conjugates. After carefully optimizing each step of the conjugation method using copper-free click-chemistry, the proFIRE® was used to separate between unconjugated IgG, single and double conjugates and the unconjugated oligo. To demonstrate the functionality of the purified antibody-DNA conjugates, a proximity ligation assay was successfully performed afterwards.

Dr. Michael Schraeml, Head Protein and Enzyme Technologies
ROCHE DIAGNOSTICS GMBH

Products for High-Performance Analysis

Biochips

switchSENSE® experiments are performed on reusable multi-electrode, multi-channels biochips.

DRX Instruments

Fully automated switchSENSE® instruments are 96-well plates compatible and manufactured in Germany.

Consumables

Including coupling kits, starter packs, training & OQ kits, as well as buffers, solutions and other consumables.

CONTACT US!
WE WILL GET IN TOUCH WITH YOU SHORTLY.

What are you interested in? *

Consumables & Reagents
Technical Support
Quotes & Orders

Instruments & Applications
Technical & Software Support
Assay Development

New to switchSENSE®
General Info & Evaluation
Purchasing

Dynamic Biosensors Data Privacy Policy

Contact Specialist