because structure means function

switchSENSE® is the first biosensor that analyzes protein conformation and analyte binding kinetics, in the same measurement, under native conditions, and with minimal sample amounts.

Analysis of PROTEIN DIAMETERS and
CONFORMATIONAL CHANGES

Introducing pure protein-DNA conjugates


pro
FIRE® is a unique system for protein-DNA conjugate preparation, delivering consistent and superior conjugate quality for your experiments.

smart biophysical analysis


switch
SENSE® instruments
for molecular interaction analysis.

switchSENSE® Technology
Molecular Interaction Analysis
Powered by
Electro-switchable Nanolevers
Unrivaled Information Content

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  • Binding Kinetics
  • Binding Affinity
  • Protein Diameter
  • Conformational Change
  • Nuclease & Polymerase Activity
  • Bispecific Binders & Avidity
  • Melting & Thermodynamics
  • Multimers & Aggregation

Application Areas

switchSENSE®
Biophysical Analysis with Electro-Switchable Biosurfaces

Join us for this recorded webinar presentation to learn more about dynamicBIOSENSORS’ pioneering switchSENSE® sensor platform: an automated, fluorescence based biosensor chip technology that employs electrically actuated DNA nanolevers for biophysical and interaction analysis measurements!

This presentation covers the different measurement modes of our novel switchSENSE® technology, as well as its applications in biophysical analysis.

In Focus

Paper in frontier in Immunology

Utilization of Staphylococcal Immune Evasion Protein Sbi as a Novel Vaccine Adjuvant

Jan. 11, 2019

Scientists from the University of Bath investigated the mechanism of action of Sbi-III-IV and how to harness it as novel vaccine adjuvant. Hereby the switchSENSE® technology was used to characterize binding kinetics and protein size changes of Sbi-III-IV-cys or it’s mutants (K173A and R231A) with C3d. Assessment of the C3d binding affinity shows that contrary to R231A the C3d binding capacity of K173A is unaffected, indicating it is essential for the role for domain III in the futile consumption of C3. Interestingly, the switchSENSE® size analyses show a reduced hydrodynamic diameter for K173A compared to WT and the C3d impaired binding mutant R231A – an indication that this mutation in domain III results in a more compact Sbi:C3d complex. These structural differences agree very well with SAXS measurements.

Paper in ACS Appl. Mater. Interfaces

Magnesium-Dependent Electrical Actuation and Stability of DNA Origami Rods

Dec. 25th, 2018

Together with scientists from the Technical University of Dresden, we used the switchSENSE® technology to study the behavior of large DNA-origami rods under different magnesium concentrations when exposed to an actuating potential.

The origami show a stable motion even in a magnesium free environment and their motion is independent of the charging time of the driving electrode. In addition, we found a correlation between the charge of origami and DNA rods with their sensitivity to the electric actuation.

 

Dr. Michael Schraeml, Head Protein and Enzyme Technologies
ROCHE DIAGNOSTICS GMBH

Products for High-Performance Analysis

Biochips

switchSENSE® experiments are performed on reusable multi-electrode, multi-channels biochips.

DRX Instruments

Fully automated switchSENSE® instruments are 96-well plates compatible and manufactured in Germany.

Consumables

Including coupling kits, starter packs, training & OQ kits, as well as buffers, solutions and other consumables.

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