because structure means function
switchSENSE® is the first biosensor that analyzes protein conformation and analyte binding kinetics, in the same measurement, under native conditions, and with minimal sample amounts.
Analysis of PROTEIN DIAMETERS and
Introducing pure protein-DNA conjugates
proFIRE® is a unique system for protein-DNA conjugate preparation, delivering consistent and superior conjugate quality for your experiments.
smart biophysical analysis
for molecular interaction analysis.
Molecular Interaction Analysis
Unrivaled Information Content
- Binding Kinetics
- Binding Affinity
- Protein Diameter
- Conformational Change
- Nuclease & Polymerase Activity
- Bispecific Binders & Avidity
- Melting & Thermodynamics
- Multimers & Aggregation
Biophysical Analysis with Electro-Switchable Biosurfaces
Join us for this recorded webinar presentation to learn more about dynamicBIOSENSORS’ pioneering switchSENSE® sensor platform: an automated, fluorescence based biosensor chip technology that employs electrically actuated DNA nanolevers for biophysical and interaction analysis measurements!
This presentation covers the different measurement modes of our novel switchSENSE® technology, as well as its applications in biophysical analysis.
Paper in frontier in Immunology
Jan. 11, 2019
Scientists from the University of Bath investigated the mechanism of action of Sbi-III-IV and how to harness it as novel vaccine adjuvant. Hereby the switchSENSE® technology was used to characterize binding kinetics and protein size changes of Sbi-III-IV-cys or it’s mutants (K173A and R231A) with C3d. Assessment of the C3d binding affinity shows that contrary to R231A the C3d binding capacity of K173A is unaffected, indicating it is essential for the role for domain III in the futile consumption of C3. Interestingly, the switchSENSE® size analyses show a reduced hydrodynamic diameter for K173A compared to WT and the C3d impaired binding mutant R231A – an indication that this mutation in domain III results in a more compact Sbi:C3d complex. These structural differences agree very well with SAXS measurements.
Paper in ACS Appl. Mater. Interfaces
Dec. 25th, 2018
Together with scientists from the Technical University of Dresden, we used the switchSENSE® technology to study the behavior of large DNA-origami rods under different magnesium concentrations when exposed to an actuating potential.
The origami show a stable motion even in a magnesium free environment and their motion is independent of the charging time of the driving electrode. In addition, we found a correlation between the charge of origami and DNA rods with their sensitivity to the electric actuation.
Dr. Michael Schraeml, Head Protein and Enzyme Technologies
ROCHE DIAGNOSTICS GMBH
Products for High-Performance Analysis
switchSENSE® experiments are performed on reusable multi-electrode, multi-channels biochips.
Fully automated switchSENSE® instruments are 96-well plates compatible and manufactured in Germany.
Including coupling kits, starter packs, training & OQ kits, as well as buffers, solutions and other consumables.