switchSENSE®
eLearning Center
We cover an array of various, different applications.
Browse through publications, application notes,
tutorials, and more.
DNA/RNA Binders
Measure the kinetics and affinities of DNA/RNA binding proteins directly with switchSENSE®’s unique DNA nanolever approach.
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Multi-specific Binders
Unravel the behaviour of complex binders like antibodies, PROTACs, and other ternary complexes with switchSENSE®’s versatile binding assays.
Conformation & Size
Solve the structure=function equation and study conformational changes in real-time with switchSENSE®’s dynamic measurement mode.
HIGHLIGHTING
Bivalent and Bispecific Binders Tutorial
Join us for this tutorial to see how our heliX® biosensor can be used to assay a broad range of bispecific analytes using the same workflow. Our automated solutions enable you to have full control over the surface-functionalization of your ligands, from density control, to dual antigen immobilization at pre-determined ratios. And with such control over the assay setup, you can evaluate features beyond target affinity, most notably ternary complex stability, impact of linker length on avidity binding, and target cell selectivity as a function of antigen abundance and spatial separation.
Using our powerful heliOS software, evaluate your readout to measure enhanced target engagement, and determining binding half-times for the affinity ranking of your bispecific analytes to their targets.
Molecule Type
Analytical Method
Application of the switchSENSE® Technique for the Study of Small Molecules’ (Ethidium Bromide and Selected Sulfonamide Derivatives) Affinity to DNA in Real Time
Characterization of binding interactions of SARS-CoV-2 spike protein and DNA-peptide nanostructures
A Robust Assay to Monitor Ataxin-3 Amyloid Fibril Assembly
Highly shape- and size-tunable membrane nanopores made with DNA
Multivalent Binding Kinetics Resolved by Fluorescence Proximity Sensing
Tight Binders Tutorial
Molecular interactions with nucleic acids: Studying nucleic acid binding molecules with switchSENSE®
The role of DNA nanostructures in the catalytic properties of an allosterically regulated protease
Measuring Influenza A Virus and Peptide Interaction Using Electrically Controllable DNA Nanolevers
Kinetics of multispecific molecules: Analysis of cooperative binding with switchSENSE®
Regulation of cadherin dimerization by chemical fragments as a trigger to inhibit cell adhesion
Electrically Switchable Nanolever Technology for the Screening of Metal-Chelating Peptides in Hydrolysates
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