switchSENSE®
eLearning Center
We cover an array of various, different applications.
Browse through publications, application notes,
tutorials, and more.
DNA/RNA Binders
Measure the kinetics and affinities of DNA/RNA binding proteins directly with switchSENSE®’s unique DNA nanolever approach.
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Multi-specific Binders
Unravel the behaviour of complex binders like antibodies, PROTACs, and other ternary complexes with switchSENSE®’s versatile binding assays.
Conformation & Size
Solve the structure=function equation and study conformational changes in real-time with switchSENSE®’s dynamic measurement mode.
HIGHLIGHTING
Bivalent and Bispecific Binders Tutorial
Join us for this tutorial to see how our heliX® biosensor can be used to assay a broad range of bispecific analytes using the same workflow. Our automated solutions enable you to have full control over the surface-functionalization of your ligands, from density control, to dual antigen immobilization at pre-determined ratios. And with such control over the assay setup, you can evaluate features beyond target affinity, most notably ternary complex stability, impact of linker length on avidity binding, and target cell selectivity as a function of antigen abundance and spatial separation.
Using our powerful heliOS software, evaluate your readout to measure enhanced target engagement, and determining binding half-times for the affinity ranking of your bispecific analytes to their targets.
Molecule Type
Analytical Method
heliX Adapter Chip Storage and Handling
Programmable multispecific DNA-origami-based T-cell engagers
Synthetic Antigen-Conjugated DNA Systems for Antibody Detection and Characterization
switchSENSE®: comprehensive characterization of molecule-molecule interactions
Plant polygalacturonase structures specify enzyme dynamics and processivities to fine-tune cell wall pectins
RT-IC Binding kinetics on cells
Kinetic analysis of ternary and binary binding modes of the bispecific antibody emicizumab
The Impact of Nε-Acryloyllysine Piperazides on the Conformational Dynamics of Transglutaminase 2
switchSENSE® Compatibility Sheet
DNA Y-structure: Analysis of ternary complex formation
Application of the switchSENSE® Technique for the Study of Small Molecules’ (Ethidium Bromide and Selected Sulfonamide Derivatives) Affinity to DNA in Real Time
The DNA-damage kinase ATR activates the FANCD2-FANCI clamp by priming it for ubiquitination
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