switchSENSE®

eLearning Center

We cover an array of various, different applications.
Browse through publications, application notes,
tutorials, and more.

DNA/RNA Binders

Measure the kinetics and affinities of DNA/RNA binding proteins directly with switchSENSE®’s unique DNA nanolever approach.

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Antibodies / Bispecifics

Unravel the behaviour of complex binders like antibodies and other bispecifics with switchSENSE®’s versatile binding assays.

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Conformation & Size

Solve the structure=function equation and study conformational changes in real-time with switchSENSE®’s dynamic measurement mode.

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HIGHLIGHTING

Bivalent and Bispecific Binders Tutorial

Join us for this tutorial to see how our heliX® biosensor can be used to assay a broad range of bispecific analytes using the same workflow. Our automated solutions enable you to have full control over the surface-functionalization of your ligands, from density control, to dual antigen immobilization at pre-determined ratios. And with such control over the assay setup, you can evaluate features beyond target affinity, most notably ternary complex stability, impact of linker length on avidity binding, and target cell selectivity as a function of antigen abundance and spatial separation. ​

Using our powerful heliOS software, evaluate your readout to measure enhanced target engagement, and determining binding half-times for the affinity ranking of your bispecific analytes to their targets. ​

CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS

CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS

switchSENSE technology for analysis of DNA polymerase kinetics

switchSENSE technology for analysis of DNA polymerase kinetics

Affinity of chlordecone and chlordecol for human serum lipoproteins

Affinity of chlordecone and chlordecol for human serum lipoproteins

Sinorhizobium meliloti YrbA binds divalent metal cations using two conserved histidines

Sinorhizobium meliloti YrbA binds divalent metal cations using two conserved histidines

Nucleotide binding kinetics and conformational change analysis of tissue transglutaminase with switchSENSE

Nucleotide binding kinetics and conformational change analysis of tissue transglutaminase with switchSENSE

The trimer to monomer transition of Tumor Necrosis Factor-Alpha is a dynamic process that is significantly altered by therapeutic antibodies

The trimer to monomer transition of Tumor Necrosis Factor-Alpha is a dynamic process that is significantly altered by therapeutic antibodies

Single-Molecule Sensing of DNA Intercalating Drugs in Water

Single-Molecule Sensing of DNA Intercalating Drugs in Water

An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2

An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2

Preparation of single- and double-oligonucleotide antibody conjugates and their application for protein analytics

Preparation of single- and double-oligonucleotide antibody conjugates and their application for protein analytics

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info@dynamic-biosensors.com

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