We cover an array of various, different applications.
Browse through publications, application notes,
tutorials, and more.
Measure the kinetics and affinities of DNA/RNA binding proteins directly with switchSENSE®’s unique DNA nanolever approach.
Unravel the behaviour of complex binders like antibodies, PROTACs, and other ternary complexes with switchSENSE®’s versatile binding assays.
Conformation & Size
Solve the structure=function equation and study conformational changes in real-time with switchSENSE®’s dynamic measurement mode.
Bivalent and Bispecific Binders Tutorial
Join us for this tutorial to see how our heliX® biosensor can be used to assay a broad range of bispecific analytes using the same workflow. Our automated solutions enable you to have full control over the surface-functionalization of your ligands, from density control, to dual antigen immobilization at pre-determined ratios. And with such control over the assay setup, you can evaluate features beyond target affinity, most notably ternary complex stability, impact of linker length on avidity binding, and target cell selectivity as a function of antigen abundance and spatial separation.
Using our powerful heliOS software, evaluate your readout to measure enhanced target engagement, and determining binding half-times for the affinity ranking of your bispecific analytes to their targets.
Highly shape- and size-tunable membrane nanopores made with DNA
Tight Binders Tutorial
Molecular interactions with nucleic acids: Studying nucleic acid binding molecules with switchSENSE®
The role of DNA nanostructures in the catalytic properties of an allosterically regulated protease
Measuring Influenza A Virus and Peptide Interaction Using Electrically Controllable DNA Nanolevers
Kinetics of multispecific molecules: Analysis of cooperative binding with switchSENSE®
Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action
heliX® Bivalent and Bispecific Binders Tutorial
Target selectivity of multispecific antibodies: practical analysis of binding kinetics and avidity
Macromolecular interactions in vitro, comparing classical and novel approaches
CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS
Standard operation procedure for switchSENSE DRX systems
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