We cover an array of various, different applications.
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Measure the kinetics and affinities of DNA/RNA binding proteins directly with switchSENSE®’s unique DNA nanolever approach.
Unravel the behaviour of complex binders like antibodies, PROTACs, and other ternary complexes with switchSENSE®’s versatile binding assays.
Conformation & Size
Solve the structure=function equation and study conformational changes in real-time with switchSENSE®’s dynamic measurement mode.
Bivalent and Bispecific Binders Tutorial
Join us for this tutorial to see how our heliX® biosensor can be used to assay a broad range of bispecific analytes using the same workflow. Our automated solutions enable you to have full control over the surface-functionalization of your ligands, from density control, to dual antigen immobilization at pre-determined ratios. And with such control over the assay setup, you can evaluate features beyond target affinity, most notably ternary complex stability, impact of linker length on avidity binding, and target cell selectivity as a function of antigen abundance and spatial separation.
Using our powerful heliOS software, evaluate your readout to measure enhanced target engagement, and determining binding half-times for the affinity ranking of your bispecific analytes to their targets.
Kinetic analysis of ternary and binary binding modes of the bispecific antibody emicizumab
The Impact of Nε-Acryloyllysine Piperazides on the Conformational Dynamics of Transglutaminase 2
DNA Y-structure: Analysis of ternary complex formation
Application of the switchSENSE® Technique for the Study of Small Molecules’ (Ethidium Bromide and Selected Sulfonamide Derivatives) Affinity to DNA in Real Time
Characterization of binding interactions of SARS-CoV-2 spike protein and DNA-peptide nanostructures
A Robust Assay to Monitor Ataxin-3 Amyloid Fibril Assembly
Highly shape- and size-tunable membrane nanopores made with DNA
Multivalent Binding Kinetics Resolved by Fluorescence Proximity Sensing
Tight Binders Tutorial
Molecular interactions with nucleic acids: Studying nucleic acid binding molecules with switchSENSE®
The role of DNA nanostructures in the catalytic properties of an allosterically regulated protease
Measuring Influenza A Virus and Peptide Interaction Using Electrically Controllable DNA Nanolevers
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