switchSENSE®

eLearning Center

We cover an array of various, different applications.
Browse through publications, application notes,
tutorials, and more.

DNA/RNA Binders

Measure the kinetics and affinities of DNA/RNA binding proteins directly with switchSENSE®’s unique DNA nanolever approach.

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Multi-specific Binders

Unravel the behaviour of complex binders like antibodies, PROTACs, and other ternary complexes with switchSENSE®’s versatile binding assays.

Conformation & Size

Solve the structure=function equation and study conformational changes in real-time with switchSENSE®’s dynamic measurement mode.

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HIGHLIGHTING

Bivalent and Bispecific Binders Tutorial

Join us for this tutorial to see how our heliX® biosensor can be used to assay a broad range of bispecific analytes using the same workflow. Our automated solutions enable you to have full control over the surface-functionalization of your ligands, from density control, to dual antigen immobilization at pre-determined ratios. And with such control over the assay setup, you can evaluate features beyond target affinity, most notably ternary complex stability, impact of linker length on avidity binding, and target cell selectivity as a function of antigen abundance and spatial separation. ​

Using our powerful heliOS software, evaluate your readout to measure enhanced target engagement, and determining binding half-times for the affinity ranking of your bispecific analytes to their targets. ​

Kinetic analysis of ternary and binary binding modes of the bispecific antibody emicizumab

Kinetic analysis of ternary and binary binding modes of the bispecific antibody emicizumab

The Impact of N<sup>ε</sup>-Acryloyllysine Piperazides on the Conformational Dynamics of Transglutaminase 2

The Impact of Nε-Acryloyllysine Piperazides on the Conformational Dynamics of Transglutaminase 2

DNA Y-structure: Analysis of ternary complex formation

DNA Y-structure: Analysis of ternary complex formation

Application of the switchSENSE® Technique for the Study of Small Molecules’ (Ethidium Bromide and Selected Sulfonamide Derivatives) Affinity to DNA in Real Time

Application of the switchSENSE® Technique for the Study of Small Molecules’ (Ethidium Bromide and Selected Sulfonamide Derivatives) Affinity to DNA in Real Time

Characterization of binding interactions of SARS-CoV-2 spike protein and DNA-peptide nanostructures

Characterization of binding interactions of SARS-CoV-2 spike protein and DNA-peptide nanostructures

A Robust Assay to Monitor Ataxin-3 Amyloid Fibril Assembly

A Robust Assay to Monitor Ataxin-3 Amyloid Fibril Assembly

Highly shape- and size-tunable membrane nanopores made with DNA

Highly shape- and size-tunable membrane nanopores made with DNA

Multivalent Binding Kinetics Resolved by Fluorescence Proximity Sensing

Multivalent Binding Kinetics Resolved by Fluorescence Proximity Sensing

Molecular interactions with nucleic acids: Studying nucleic acid binding molecules with switchSENSE®

Molecular interactions with nucleic acids: Studying nucleic acid binding molecules with switchSENSE®

The role of DNA nanostructures in the catalytic properties of an allosterically regulated protease

The role of DNA nanostructures in the catalytic properties of an allosterically regulated protease

Measuring Influenza A Virus and Peptide Interaction Using Electrically Controllable DNA Nanolevers

Measuring Influenza A Virus and Peptide Interaction Using Electrically Controllable DNA Nanolevers

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