switchSENSE®

eLearning Center

We cover an array of various, different applications.
Browse through publications, application notes,
tutorials, and more.

DNA/RNA Binders

Measure the kinetics and affinities of DNA/RNA binding proteins directly with switchSENSE®’s unique DNA nanolever approach.

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Antibodies / Bispecifics

Unravel the behaviour of complex binders like antibodies and other bispecifics with switchSENSE®’s versatile binding assays.

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Conformation & Size

Solve the structure=function equation and study conformational changes in real-time with switchSENSE®’s dynamic measurement mode.

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HIGHLIGHTING

Multiplex DNA-Binder Tutorial

In this 20 min tutorial, learn how easy it is to measure kinetics of a DNA-binding protein to 4 targets simultaneously with our new heliX® biosensor.

We are analyzing association and dissociation rates, and KD values to understand how changes in a target DNA sequence, the T7 promoter, affect T7 RNA polymerase binding kinetics. Watch the video to learn how heliX® enables you to multiplex your molecular interaction studies in a user friendly, cost effective, and reproducible way.

CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS

CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS

switchSENSE technology for analysis of DNA polymerase kinetics

switchSENSE technology for analysis of DNA polymerase kinetics

Affinity of chlordecone and chlordecol for human serum lipoproteins

Affinity of chlordecone and chlordecol for human serum lipoproteins

Sinorhizobium meliloti YrbA binds divalent metal cations using two conserved histidines

Sinorhizobium meliloti YrbA binds divalent metal cations using two conserved histidines

Nucleotide binding kinetics and conformational change analysis of tissue transglutaminase with switchSENSE

Nucleotide binding kinetics and conformational change analysis of tissue transglutaminase with switchSENSE

The trimer to monomer transition of Tumor Necrosis Factor-Alpha is a dynamic process that is significantly altered by therapeutic antibodies

The trimer to monomer transition of Tumor Necrosis Factor-Alpha is a dynamic process that is significantly altered by therapeutic antibodies

An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2

An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2

Preparation of single- and double-oligonucleotide antibody conjugates and their application for protein analytics

Preparation of single- and double-oligonucleotide antibody conjugates and their application for protein analytics

Validation of the Slow Off-Kinetics of Sirtuin-Rearranging Ligands (SirReals) by Means of Label-Free Electrically Switchable Nanolever Technology

Validation of the Slow Off-Kinetics of Sirtuin-Rearranging Ligands (SirReals) by Means of Label-Free Electrically Switchable Nanolever Technology

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info@dynamic-biosensors.com

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