switchSENSE®

eLearning Center

We cover an array of various, different applications.
Browse through publications, application notes,
tutorials, and more.

DNA/RNA Binders

Measure the kinetics and affinities of DNA/RNA binding proteins directly with switchSENSE®’s unique DNA nanolever approach.

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Multi-specific Binders

Unravel the behaviour of complex binders like antibodies, PROTACs, and other ternary complexes with switchSENSE®’s versatile binding assays.

Conformation & Size

Solve the structure=function equation and study conformational changes in real-time with switchSENSE®’s dynamic measurement mode.

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HIGHLIGHTING

Bivalent and Bispecific Binders Tutorial

Join us for this tutorial to see how our heliX® biosensor can be used to assay a broad range of bispecific analytes using the same workflow. Our automated solutions enable you to have full control over the surface-functionalization of your ligands, from density control, to dual antigen immobilization at pre-determined ratios. And with such control over the assay setup, you can evaluate features beyond target affinity, most notably ternary complex stability, impact of linker length on avidity binding, and target cell selectivity as a function of antigen abundance and spatial separation. ​

Using our powerful heliOS software, evaluate your readout to measure enhanced target engagement, and determining binding half-times for the affinity ranking of your bispecific analytes to their targets. ​

Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action

Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action

heliX® Bivalent and Bispecific Binders Tutorial

heliX® Bivalent and Bispecific Binders Tutorial

Target selectivity of multispecific antibodies: practical analysis of binding kinetics and avidity

Target selectivity of multispecific antibodies: practical analysis of binding kinetics and avidity

Macromolecular interactions in vitro, comparing classical and novel approaches

Macromolecular interactions in vitro, comparing classical and novel approaches

CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS

CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS

Standard operation procedure for switchSENSE DRX systems

Standard operation procedure for switchSENSE DRX systems

switchSENSE technology for analysis of DNA polymerase kinetics

switchSENSE technology for analysis of DNA polymerase kinetics

Affinity of chlordecone and chlordecol for human serum lipoproteins

Affinity of chlordecone and chlordecol for human serum lipoproteins

Sinorhizobium meliloti YrbA binds divalent metal cations using two conserved histidines

Sinorhizobium meliloti YrbA binds divalent metal cations using two conserved histidines

Nucleotide binding kinetics and conformational change analysis of tissue transglutaminase with switchSENSE

Nucleotide binding kinetics and conformational change analysis of tissue transglutaminase with switchSENSE

Contact Us

Discuss your specific needs with our specialists.

info@dynamic-biosensors.com

+49 89 89 74 544-0

Lochhamer Str. 15, 82152 Martinsried/Planegg, Germany

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