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The DRX2 instrument serves a wide range of users with many different applications in our biophysics core facility in our institute. We find that switchSENSE® technology is an excellent addition to our facility because of its reliability and accuracy in measuring intermolecular interactions across a very wide spectrum of biological applications.
We are also very impressed with its ease of use, which significantly lowers the bar to getting started and obtaining publishable data in just couple of hours. dynamicBIOSENSORS staff are also extremely helpful and knowledgeable in not only troubleshooting technical issues with the instrument operation but also in suggesting improvements to experimental design – something we hugely appreciate.
Of the last four big instruments I have bought in the last year, a superresolution microscope, a potentiostat, a fancy gradient maker/fractionator, and the proFIRE®, I would say it is by far the most robust and easy to use.
When I look back over about 15 big lab instruments over the last 20 years, I would say it is one of the top 10% in terms of robustness and ease of use, if it separates the compounds you want to separate (which dynamicBIOSENSORS is great about testing first before you buy).
At Merck, we see the switchSENSE® technology as a versatile and highly valuable tool to positively impact preclinical drug discovery projects. switchSENSE® has proven to be extremely helpful when it comes to the analysis of interactions between a drug candidate and its target protein.
Especially the formation of ternary complexes (DNA-Enzyme-Drug) and being able to detect the inhibition of the enzymatic activity is a big benefit. Moreover, we highly appreciate the support and the competence of the dynamicBIOSENSORS team.
switchSENSE® biosensor will certainly increase CCMAR’s scientific capacity, but it should be seen as a far-reaching investment, first because it can also be used by the entire academic and industrial community, and second because it will enable us to identify more rapidly new biomolecules of marine origin with potential for human use.
switchSENSE® gives researchers new tools to understanding protein-ligand interaction by combining traditional kinetics measurements with changes in molecular size and shape.
Our lab used the ultra-high sensitivity switchSENSE® technology from Dynamic Biosensors to confirm the pM affinities of our Nano-Traps. switchSENSE® also confirmed structural data through its rapid absolute sizing model.
switchSENSE® allows us to measure affinity and kinetics of DNA-binding proteins which we are unable to analyze with any other method. Even more, switchSENSE® enables us to go one step further and characterize the enzymatic function of those proteins due to its unique dynamic measurement mode.
A remarkable technology for a fresh new angle on molecular interaction.
switchSENSE® is one of the few new technologies which provide a clear value-added. In the case of switchSENSE®, this is the additional information on size and conformational changes of the binding partners. Especially the observation of conformational changes upon binding can be of great value to researchers in small molecule research.
We have tested switchSENSE® with a well-characterized ligand-receptor interaction. I was amazed how switchSENSE® allows to track each single measurement step in detail and about the wealth of information this technology provides. Binding parameters as well as sizing data confirmed our previous results from many previously conducted experiments – all in one single measurement.
switchSENSE® was a revelation: it solved a seemingly intractable antibody/antigen measurement with ease. The key was its remarkably versatile architecture, switchSENSE® seems only limited by the imagination of the researcher.
We have used switchSENSE® to characterize the binding of insuline to a certain receptor. I am amazed by the wealth of information we could extract from these measurements. Apart from mere binding studies, the function of the signaling pathway could be traced in detail with switchSENSE®. This would not have been possible with any conventional sensor system.
Conformational change provides a more biologically relevant description of molecular interactions than just kinetics alone. Using switchSENSE® will enable us to accelerate our pursuit of breakthrough molecules.
The architectures available from switchSENSE® are uniquely placed to offer us the flexibility and extraordinary sensitivity in our molecular interaction studies. This new technology will immediately open up a number of new research approaches, previously unattainable from existing technologies.
switchSENSE® gives imaginative researchers a fresh new set of options for studying molecular interactions.
We have been using dynamicBIOSENSORS’ DRX 2400 instrument for biomarker analysis and research for quite a while now. What strikes me is the enormous flexibility and versatility the system provides. I do not know of any other system which allows the analysis of protein and DNA biomarkers on the same chip in the same measurement.