Webinar I April 17, 2024

DISCOVER small molecule-induced protein conformational changes using DNA origami nanolevers

This is the sixth episode of our second season of the DISCOVER MOLECULAR INTERACTIONS webinar series. Each month we will talk about cutting-edge drug discovery topics like bispecific antibodies, PROTACs or small molecules targeting RNA. We will show you how to characterize the respective molecular interactions in depth, how to create assays with remarkable biological similarity, low sample consumption, high versatility and exceptional ease-of-use.In this episode we will not look at binding kinetics, but instead at another effect molecular interactions can provoke: the conformational change of a protein. Small molecule drugs are increasingly investigated for their influence on protein conformation to exert their therapeutic effect as this mode of action can overcome drug resistances. We will show how conformational changes in proteins can be detected using switchSENSE®and DNA origami nanolevers which are oscillated at high speed. Several application examples will be presented ranging from human physiology to infection biology to cancer research.

If you are interested in another application, you can find all future episodes of this webinar series here

DISCOVER MOLECULAR INTERACTIONS webinar series