Read full Article Publication I April 28, 2022 Multivalent Binding Kinetics Resolved by Fluorescence Proximity Sensing Multivalent protein interactors are an attractive modality for probing protein function and exploring novel pharmaceutical strategies. The throughput...
Read full Article Publication I June 18, 2021 Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action The receptor tyrosine kinase HER2 acts as oncogenic driver in numerous cancers. Usually, the gene is amplified, resulting in receptor...
Read full Article Publication I March 30, 2021 CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS Through dominant mutations, aminoacyl-tRNA synthetases constitute the largest protein family linked to Charcot-Marie-Tooth disease (CMT). An...
Read full Article Publication I March 11, 2020 Resolving Binding Events on the Multifunctional Human Serum Albumin Physiological processes rely on initial recognition events between cellular components and other molecules or modalities. Biomolecules can have multiple...
Read full Article Publication I September 9, 2019 CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells Aminoacyl-transfer RNA (tRNA) synthetases (aaRSs) are the largest protein...
