Biophysical Analysis of Molecular Interactions

switchSENSE® User Meetings:
interACT!

Don´t miss out on the latest developments in multi-parameter biophysical analysis of molecular interactions.
Join a variety of scientific talks & participate in technical tutorials in a relaxed atmosphere.

BE INSPIRED, interACT!, ENGAGE & LEARN. 


switch
SENSE® User Meetings attract leading scientists and speakers from around the world.
interACT! with experts from academia and industry who will be sharing their work in areas from basic research to quality control using switchSENSE® technology.

switchSENSE® User Meetings:
Conference Topics

ANTIBODIES & BISPECIFICS
Avidity vs. affinity

Bispecific antibodies form a valuable class of therapeutic agents due to their ability to engage two distinct targets simultaneously. Dual targeting is thought to enhance biological efficacy and increase target selectivity via avidity effect upon binding to both antigens on the surface of the same cell. switchSENSE® biosensor design enables to mimic cell surfaces through the immobilization of two different target antigens on its sensor surface. The precise control over the relative abundance and the spatial arrangement of two target species on the sensor surface is achieved using DNA-guided antigen functionalization and simultaneous dual-color fluorescence detection. The quantitative analysis of individual and cooperative target binding provides invaluable insight, supporting the engineering of the antibody’s individual affinities to achieve minimal off-target binding and maximize selectivity.

DNA / RNA - PROTEIN INTERACTIONS
CRISPR/Cas9, polymerases, transcription factors

Cellular processes such as transcription, translation, or replication require the tightly controlled interaction of proteins with DNA and RNA. The oligonucleotides immobilized on switchSENSE® biosensors are ideally suited as ‘anchors’ to functionalize the sensor surface with DNA or RNA targets of interest, and these targets can be exchanged on the sensor in a straightforward manner through standardized hybridization and washing protocols. Long-ranged fluorescence energy transfer to the supporting gold serves as a molecular ruler to observe movement of proteins along the DNA/RNA molecules in real-time. Hence, enzymatic activity can be gauged.

CONFORMATIONAL CHANGE
Quantitation through Stokes radius measurement

Molecular interactions and protein function crucially depend on protein structure and often involve conformational changes. switchSENSE® is a unique platform for the analysis of conformational changes in proteins by combining high sensitivity kinetics with structural analysis. When proteins are bound to the oscillating DNA nanolevers on the switchSENSE® chip, the speed of the electrically actuated nanolevers depends on their hydrodynamic drag and can be converted to the protein’s Stokes diameter with Angstrom resolution. The kinetics of conformational changes or multi-/monomerizations are resolved by monitoring the switching speed in real-time. The conformation signal usually is clearly distinguishable from a pure binding event, and hence binding and structural changes can be detected simultaneously.

SMALL MOLECULES

Further information will follow soon.

TENTATIVE AGENDA* 2018

DAY 1 I 12:30pm – 05:00pm TALKS
DNA/RNA – Protein Interactions
TUTORIALS
Measurement Modes
DAY 2 I 09:00am – 12:30pm TALKS
Antibodies & Bispecifics
TUTORIALS
Surface Functionalization & Ligand Density Control
  01:30pm –
05:00pm
TALKS
Conformational Change
TUTORIALS
Size Analysis
DAY 3 I 09:00am – 12:30pm TALKS
Small Molecules
TUTORIALS
Data Analysis
  02:00pm –
04:00pm
LAB COURSES
Do it Yourself!
 

*This agenda is subject to change.
CLICK HERE TO DOWNLOAD
Detailed programs of our 2018 user meetings will be available soon.

TUTORIALS

Join our switchSENSE® tutorials offered during the user meetings in Munich and San Diego at no extra cost

  • Measurement modes
  • Surface functionalization & ligand density control
  • Size analysis
  • Data analysis

DO IT YOURSELF!

During our user meetings in Munich and San Diego we also offer you optional LAB COURSES.
Hands-on 
switchSENSE® experiments with DRX and DRX2 instruments, assisted by DBS scientists.
Samples are provided by Dynamic Biosensors.

Speak at our 2018 User Meetings


Our 2018 switchSENSE® User Meetings are a great opportunity to showcase your research. 

Are you interested in giving a presentation? Great to hear! 

Abstracts must describe original work and should not be more than 300 words / max. 2.000 characters long. 
The deadline for submitting your abstract is May 15th, 2018.

Please use this template and email your abstract to events@dynamic-biosensors.com

Registration

Please fill out the following form to register for the switchSENSE® User Meeting:

I would like to participate in the User Meeting 2018 in Munich, DE / 06-08 June 2018
I would like to participate in the User Meeting 2018 in San Diego, USA / 20-22 June 2018
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I would like to give a talk and therefore submit an abstract.
Please use this template and email your abstract to events@dynamic-biosensors.com

 

Registration fees
till 30 April 2018

 

  • 180 EUR / 220 USD for participants from industry
  • 120 EUR / 150 USD for participants from academia


after 30 April 2018

 

  • 220 EUR / 270 USD for participants from industry
  • 160 EUR / 200 USD for participants from academia

Please be advised that photographs and/or videos will be taken during our events. By taking part in our user meetings you grant the event organizers full rights to use the images resulting from the photography/video filming, and any reproductions or adaptations of the images for use on the DBS website and in the press, our marketing materials, and other DBS publications.

If you do not wish to be photographed, please inform us in advance.
Thank you for your understanding. 

Hotel Information

A limited number of rooms are available at the Motel One Munich-City-West at the standard rate of 79,00 € per night/single room and at the Novotel Munich City Arnulfpark at a reduced rate of 130,00 € per night/single room (till 15th of May).

If you´d like to book your room in one of these hotels, please make sure to use the keyword “switchSENSE User Meeting 2018” when contacting the hotel for reservation. Thank you. 

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WE WILL GET IN TOUCH WITH YOU SHORTLY.

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