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Insight into the avidity–affinity relationship of the bivalent, pH-dependent interaction between IgG and FcRn

Read full Article Publication I June 7, 2024 Insight into the avidity–affinity relationship of the bivalent, pH-dependent interaction between IgG and FcRn Monoclonal antibodies (mAbs) as therapeutics necessitate favorable pharmacokinetic properties, including extended...

Real-time measurement of DNA polymerase activity and inhibition with switchSENSE® and the heliX® biosensor

Read More App Note Real-time measurement of DNA polymerase activity and inhibition with switchSENSE® and the heliX® biosensor Polymerases play a key role in all living cells for the replication and preservation of genetic information. They are also interesting drug...

Reverse transcription as key step in RNA in vitro evolution with unnatural base pairs

Read full Article Publication I April 23, 2024 Reverse transcription as key step in RNA in vitro evolution with unnatural base pairs Unnatural base pairs (UBPs) augment the chemical diversity of artificial nucleic acids and can thus enable the generation of new...

Balancing the Affinity and Tumor Cell Binding of a Two-in-One Antibody Simultaneously Targeting EGFR and PD-L1

Read full Article Publication I May 2, 2024 Balancing the Affinity and Tumor Cell Binding of a Two-in-One Antibody Simultaneously Targeting EGFR and PD-L1 The optimization of the affinity of monoclonal antibodies is crucial for the development of drug candidates, as...

switchSENSE®: comprehensive characterization of molecule-molecule interactions

Download Brochure Brochure I May 15, 2024 switchSENSE® comprehensive characterization of molecule-molecule interactions This brochure explains how to analyze interactions of any molecule of your interest, ranging from small molecules to antibodies. switchSENSE®...
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