Read full Article Publication I February 16, 2024 Repurposing the mammalian RNA-binding protein Musashi-1 as an allosteric translation repressor in bacteria The RNA recognition motif (RRM) is the most common RNA-binding protein domain identified in nature. However,...
Read full Article Publication I May 2, 2024 Balancing the Affinity and Tumor Cell Binding of a Two-in-One Antibody Simultaneously Targeting EGFR and PD-L1 The optimization of the affinity of monoclonal antibodies is crucial for the development of drug candidates, as...
View Webinar Webinar I April 17, 2024 DISCOVER therapeutic antibodies: kinetics of antibody-drug conjugates measured directly on cells This is the third episode of our second season of the DISCOVER MOLECULAR INTERACTIONS webinar series. Each month we will talk about...
Read full Article Publication I December 7, 2023 Kinetic FRET Assay to Measure Binding-Induced Conformational Changes of Nucleic Acids The interaction of small molecules or proteins with RNA or DNA often involves changes in the nucleic acid (NA) folding and structure....
Read full Article Publication I November 27, 2023 Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction The classical Non-Homologous End Joining (c-NHEJ) pathway is the predominant process in mammals...
