Kinetics / Affinity / Avidity | Dynamic Biosensors

Nucleotide binding kinetics and conformational change analysis of tissue transglutaminase with switchSENSE

Nucleotide binding kinetics and conformational change analysis of tissue transglutaminase with switchSENSE I Paper Function, activity, and interactions of proteins crucially depend on their three-dimensional structure and are often regulated by effector binding and...

The trimer to monomer transition of Tumor Necrosis Factor-Alpha is a dynamic process that is significantly altered by therapeutic antibodies

The trimer to monomer transition of Tumor Necrosis Factor-Alpha is a dynamic process that is significantly altered by therapeutic antibodies I Paper The cytokine tumor necrosis factor-alpha (TNF-α) readily forms homotrimers at sub-nM concentrations to promote...

An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2

An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2 I Paper The recognition of cis-regulatory RNA motifs in human transcripts by RNA binding proteins (RBPs) is essential for gene regulation. The molecular...

Validation of the Slow Off-Kinetics of Sirtuin-Rearranging Ligands (SirReals) by Means of Label-Free Electrically Switchable Nanolever Technology

Validation of the Slow Off-Kinetics of Sirtuin-Rearranging Ligands (SirReals) by Means of Label-Free Electrically Switchable Nanolever Technology I Paper We have discovered the sirtuin‐rearranging ligands (SirReals) to be highly potent and selective inhibitors of...

FOXP2 Oligomerization and DNA Binding

Dissecting FOXP2 Oligomerization and DNA Binding I Publication Protein–protein and protein–substrate interactions are critical to function and often depend on factors that are difficult to disentangle. Herein, a combined biochemical and biophysical approach, based on...

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Nucleotide binding kinetics and conformational change analysis of tissue transglutaminase with switchSENSE

The trimer to monomer transition of Tumor Necrosis Factor-Alpha is a dynamic process that is significantly altered by therapeutic antibodies

An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2

Validation of the Slow Off-Kinetics of Sirtuin-Rearranging Ligands (SirReals) by Means of Label-Free Electrically Switchable Nanolever Technology

FOXP2 Oligomerization and DNA Binding

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