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Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action

Read full Article Publication I June 18, 2021 Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action The receptor tyrosine kinase HER2 acts as oncogenic driver in numerous cancers. Usually, the gene is amplified, resulting in receptor...

CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS

Read full Article Publication I March 30, 2021 CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS Through dominant mutations, aminoacyl-tRNA synthetases constitute the largest protein family linked to Charcot-Marie-Tooth disease (CMT). An...

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