Read full Article Publication I June 7, 2024 Insight into the avidity–affinity relationship of the bivalent, pH-dependent interaction between IgG and FcRn Monoclonal antibodies (mAbs) as therapeutics necessitate favorable pharmacokinetic properties, including extended...
Read full Article Publication I April 23, 2024 Reverse transcription as key step in RNA in vitro evolution with unnatural base pairs Unnatural base pairs (UBPs) augment the chemical diversity of artificial nucleic acids and can thus enable the generation of new...
Read full Article Publication I February 16, 2024 Repurposing the mammalian RNA-binding protein Musashi-1 as an allosteric translation repressor in bacteria The RNA recognition motif (RRM) is the most common RNA-binding protein domain identified in nature. However,...
Read full Article Publication I May 2, 2024 Balancing the Affinity and Tumor Cell Binding of a Two-in-One Antibody Simultaneously Targeting EGFR and PD-L1 The optimization of the affinity of monoclonal antibodies is crucial for the development of drug candidates, as...
Read full Article Publication I January 18, 2024 DNA origami traps for large viruses Virus-enveloping macromolecular shells or tilings can prevent viruses from entering cells. Here, we describe the design and assembly of a cone-shaped DNA origami higher-order assembly...
