Read full Article Publication I October 27, 2022 Structural basis for Cas9 off-target activity The target DNA specificity of the CRISPR-associated genome editor nuclease Cas9 is determined by complementarity to a 20-nucleotide segment in its guide RNA. However, Cas9...
Read full Article Publication I September 15, 2022 Application of the switchSENSE® Technique for the Study of Small Molecules’ (Ethidium Bromide and Selected Sulfonamide Derivatives) Affinity to DNA in Real Time The discovery and introduction of the switchSENSE®...
Read full Article Publication I September 01, 2022 The DNA-damage kinase ATR activates the FANCD2-FANCI clamp by priming it for ubiquitination DNA interstrand cross-links are tumor-inducing lesions that block DNA replication and transcription. When cross-links are...
Read full Article Publication I April 28, 2022 Highly shape- and size-tunable membrane nanopores made with DNA Membrane nanopores are key for molecular transport in biology, portable DNA sequencing1,2,3,4, label-free single-molecule...
Download Brochure Brochure I January 24, 2022 Molecular interactions with nucleic acidsStudying nucleic acid binding molecules with switchSENSE® Easy biosensor modification with specific nucleic acid sequences Real-time off-target binding information High...
