Download Brochure Brochure I November 1, 2022 Drugging the “undruggables” Overcome the challenge of analyzing small molecules that inhibit or stabilize protein-protein interactions. Create Homo- or Hetero-protein immobilizationon the biosensor...
Read full Article Publication I October 27, 2022 Structural basis for Cas9 off-target activity The target DNA specificity of the CRISPR-associated genome editor nuclease Cas9 is determined by complementarity to a 20-nucleotide segment in its guide RNA. However, Cas9...
Read full Article Publication I September 15, 2022 Application of the switchSENSE® Technique for the Study of Small Molecules’ (Ethidium Bromide and Selected Sulfonamide Derivatives) Affinity to DNA in Real Time The discovery and introduction of the switchSENSE®...
Read full Article Publication I September 01, 2022 The DNA-damage kinase ATR activates the FANCD2-FANCI clamp by priming it for ubiquitination DNA interstrand cross-links are tumor-inducing lesions that block DNA replication and transcription. When cross-links are...
Read full Article Publication I July 27, 2022 Characterization of binding interactions of SARS-CoV-2 spike protein and DNA-peptide nanostructures Binding interactions of the spike proteins of the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) to a...
