Read full Article Publication I January 2, 2019 RNA-binding proteins distinguish between similar sequence motifs to promote targeted deadenylation by Ccr4-Not The Ccr4-Not complex removes mRNA poly(A) tails to regulate eukaryotic mRNA stability and translation....
Read full Article Publication I December 7, 2018 Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus Celastrol is a natural pentacyclic triterpene used in traditional Chinese...
Read full Article Publication I November 8, 2018 Structural and Kinetic Profiling of Allosteric Modulation of Duplex DNA Induced by DNA-Binding Polyamide Analogues A combined structural and quantitative biophysical profile of the DNA binding affinity, kinetics and...
Read full Article Publication I October 5, 2018 XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining The Ku70–Ku80 (Ku) heterodimer binds rapidly and tightly to the ends of DNA double-strand breaks and recruits factors of the...
Read full Article Publication I October 1, 2018 Assembly and Characterization of a Slingshot DNA Nanostructure for the Analysis of Bivalent and Bispecific Analytes with Biosensors The characterization of novel therapeutic antibodies with multivalent or multispecific...
