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Regulation of cadherin dimerization by chemical fragments as a trigger to inhibit cell adhesion

Read full Article Publication I September 07, 2021 Regulation of cadherin dimerization by chemical fragments as a trigger to inhibit cell adhesion Many cadherin family proteins are associated with diseases such as cancer. Since cell adhesion requires homodimerization...

Electrically Switchable Nanolever Technology for the Screening of Metal-Chelating Peptides in Hydrolysates

Read full Article Publication I April 28, 2022 Electrically Switchable Nanolever Technology for the Screening of Metal-Chelating Peptides in Hydrolysates Metal-chelating peptides (MCP) are considered as indirect antioxidants due to their capacity to inhibit radical...

Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action

Read full Article Publication I June 18, 2021 Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action The receptor tyrosine kinase HER2 acts as oncogenic driver in numerous cancers. Usually, the gene is amplified, resulting in receptor...

Biophysical Studies of the Binding of Viral RNA with the 80S Ribosome Using switchSENSE®

Read full Article Publication I April 21, 2021 ​Biophysical Studies of the Binding of Viral RNA with the 80S Ribosome Using switchSENSE®   Translation initiation, in both eukaryotes and bacteria, requires essential elements such as mRNA, ribosome , initiator tRNA, and...

Macromolecular interactions in vitro, comparing classical and novel approaches

Read full Article Publication I April 01, 2021 Macromolecular interactions in vitro, comparing classical and novel approaches Biophysical quantification of protein interactions is central to unveil the molecular mechanisms of cellular processes. Researchers can choose...
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