Read full Article Publication I August 8, 2019 A DNA-based biosensor assay for the kinetic characterization of ion-dependent aptamer folding and protein binding Therapeutic and diagnostic aptamers are nucleic acid oligomers designed to bind tightly and specifically...
Read full Article Publication I May 29, 2019 A Step-by-Step Guide to Study Protein–RNA Interactions Protein–RNA complex formation is at the center of RNA metabolism and leads to the modulation of protein and RNA functions. We propose here a step-by-step guide to...
Read full Article Publication I December 11, 2020 Triazine-Modified 7-Deaza-2′-deoxyadenosines: Better Suited for Bioorthogonal Labeling of DNA by PCR than 2′-Deoxyuridines 6-Ethynyl-1,2,4-triazine is a small bioorthogonally reactive group we applied for fluorescent...
Read full Article Publication I April 8, 2019 Specific inhibition of splicing factor activity by decoy RNA oligonucleotides Alternative splicing, a fundamental step in gene expression, is deregulated in many diseases. Splicing factors (SFs), which regulate this...
Read full Article Publication I March 19, 2019 Dissecting FOXP2 Oligomerization and DNA Binding Protein–protein and protein–substrate interactions are critical to function and often depend on factors that are difficult to disentangle. Herein, a combined biochemical...
