Which fluorescent dyes are available for switchSENSE® experiments?

The adapter strands are available with three different red and three different green fluorescent probes. The dyes differ in chemical properties to optimize the signal for your specific application. In general, we recommend to use the dye Ra, since it offers highest...

How do I perform a dye scouting?

With a simple dye scouting procedure you can easily identify the most suitable dye for your application in only 2 hours. You use the dye scouting kit and perform the usual steps of ligand preparation, functionalization and a standard kinetic assay with the different...

Which ligands can be investigated in switchSENSE®experiments?

Your ligand of interest can be a single-strand RNA or DNA sequence, a double-strand RNA or DNA sequence, an aptamer, a small molecule, a protein or peptide of any desired size, a liposome, a virus-like particle, or whatever else you can think of. If you have questions...

Which analytes can I examine with switchSENSE®?

Your analyte of interest can be anything ranging from small molecules to peptides and proteins and even multispecific binders like antibodies or PROTACs. If you have questions concerning the applicability of your specific analyte, contact our specialists!