Read full Article Publication I December 1, 2022 Kinetic analysis of ternary and binary binding modes of the bispecific antibody emicizumab The binding properties of bispecific antibodies (bsAb) are crucial for their function, especially when two antigens are targeted...
Read full Article Publication I January 13, 2023 The Impact of Nε-Acryloyllysine Piperazides on the Conformational Dynamics of Transglutaminase 2 In addition to the classic functions of proteins, such as acting as a biocatalyst or binding partner, the conformational...
Read full Article Publication I October 27, 2022 Structural basis for Cas9 off-target activity The target DNA specificity of the CRISPR-associated genome editor nuclease Cas9 is determined by complementarity to a 20-nucleotide segment in its guide RNA. However, Cas9...
Read full Article Publication I September 15, 2022 Application of the switchSENSE® Technique for the Study of Small Molecules’ (Ethidium Bromide and Selected Sulfonamide Derivatives) Affinity to DNA in Real Time The discovery and introduction of the switchSENSE®...
Read full Article Publication I September 01, 2022 The DNA-damage kinase ATR activates the FANCD2-FANCI clamp by priming it for ubiquitination DNA interstrand cross-links are tumor-inducing lesions that block DNA replication and transcription. When cross-links are...
