Read full Article Publication I November 20, 2017 Mapping the sugar dependency for rational generation of a DNA-RNA hybrid-guided Cas9 endonuclease The CRISPR–Cas9 RNA-guided endonuclease system allows precise and efficient modification of complex genomes and is...
Read full Article Publication I July 27, 2017 Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy While having multiple aminoacyl-tRNA synthetases implicated in Charcot-Marie-Tooth (CMT) disease suggests a...
Read full Article Publication I July 27, 2017 Structural study of the Fox-1 RRM protein hydration reveals a role for key water molecules in RRM-RNA recognition The Fox-1 RNA recognition motif (RRM) domain is an important member of the RRM protein family. We report a...
Read full Article Brochure I May 2, 2017 Biophysical analysis of Cas9-DNA interactions and enzymatic activity with the switchSENSE® Biosensor Platform The analysis of the biophysical properties of Cas9 – DNA interactions (binding kinetics, affinity, endonuclease...
Read full Article Publication I April 15, 2017 switchSENSE: A new technology to study protein-RNA interactions. Characterization of RNA-binding protein interactions with RNA became inevitable to properly understand the cellular mechanisms involved in gene expression...
