Read full Article Publication I June 18, 2021 Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action The receptor tyrosine kinase HER2 acts as oncogenic driver in numerous cancers. Usually, the gene is amplified, resulting in receptor...
View Video Webinar I April 21, 2021 Target selectivity of multispecific antibodies: practical analysis of binding kinetics and avidity Bispecific antibodies are promising therapeutics for targeting cancer cells with high specificity. The measurement of binding rates...
Read full Article Publication I April 01, 2021 Macromolecular interactions in vitro, comparing classical and novel approaches Biophysical quantification of protein interactions is central to unveil the molecular mechanisms of cellular processes. Researchers can choose...
Read full Article Publication I March 30, 2021 CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS Through dominant mutations, aminoacyl-tRNA synthetases constitute the largest protein family linked to Charcot-Marie-Tooth disease (CMT). An...
Read full Article Publication I March 27, 2021 Standard operation procedure for switchSENSE DRX systems There is currently a large panel of technologies available to address molecular interactions in vitro. Each technology presents individual advantages and drawbacks,...
