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ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase

Read full Article Publication I May 16, 2018 ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase Editing domains of aminoacyl tRNA synthetases correct tRNA charging errors to maintain translational fidelity. A mutation in the editing domain of...

Preclinical Development of a Novel, Orally-Administered Anti-Tumour Necrosis Factor Domain Antibody for the Treatment of Inflammatory Bowel Disease

Read full Article Publication I March 21, 2018 Preclinical Development of a Novel, Orally-Administered Anti-Tumour Necrosis Factor Domain Antibody for the Treatment of Inflammatory Bowel Disease TNFα is an important cytokine in inflammatory bowel disease. V565 is a...

High-affinity capturing of tagged proteins on the switchSENSE® biochip using Strep-Tactin®XT

Read App Note App Note I March 3, 2018 High-affinity capturing of tagged proteins on the switchSENSE® biochip using Strep-Tactin®XT Antibody oligonucleotide conjugates are playing a significant role for a wide range of diagnostic and therapeutic applications....

A low-complexity region in the YTH domain protein Mmi1 enhances RNA binding

Read full Article Publication I June 15, 2018 A low-complexity region in the YTH domain protein Mmi1 enhances RNA binding Mmi1 is an essential RNA-binding protein in the fission yeast Schizosaccharomyces pombe that eliminates meiotic transcripts during normal...

Mapping the sugar dependency for rational generation of a DNA-RNA hybrid-guided Cas9 endonuclease

Read full Article Publication I November 20, 2017 Mapping the sugar dependency for rational generation of a DNA-RNA hybrid-guided Cas9 endonuclease The CRISPR–Cas9 RNA-guided endonuclease system allows precise and efficient modification of complex genomes and is...
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