Read full Article Publication I November 20, 2017 Mapping the sugar dependency for rational generation of a DNA-RNA hybrid-guided Cas9 endonuclease The CRISPR–Cas9 RNA-guided endonuclease system allows precise and efficient modification of complex genomes and is...
Read full Article Publication I July 27, 2017 Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy While having multiple aminoacyl-tRNA synthetases implicated in Charcot-Marie-Tooth (CMT) disease suggests a...
Read full Article Brochure I May 2, 2017 Biophysical analysis of Cas9-DNA interactions and enzymatic activity with the switchSENSE® Biosensor Platform The analysis of the biophysical properties of Cas9 – DNA interactions (binding kinetics, affinity, endonuclease...
Read full Article Publication I July 10, 2013 Protein analysis by time-resolved measurements with an electro-switchable DNA chip Measurements in stationary or mobile phases are fundamental principles in protein analysis. Although the immobilization of molecules on...
Read full Article Publication I July 15, 2015 Polymerase/DNA interactions and enzymatic activity: multiparameter analysis with electroswitchable biosurfaces The engineering of high-performance enzymes for future sequencing and PCR technologies as well as the...
