A new biosensor-based assay for aptamer-protein interaction analysis

Here we show how aptamer-protein interactions can be analyzed with DNA-based biosensors. To this end, we study the salt-dependence and sequence and structure specificity of the well-characterized interaction of thrombin with its aptamer (TBA) using a simple and quick switchSENSE® assay.

The automated workflow with standard consumables can be used to study an extensive range of aptamer-target interactions in a DRX² analyzer.