Read full Article Publication I September 9, 2019 CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells Aminoacyl-transfer RNA (tRNA) synthetases (aaRSs) are the largest protein...
Read full Article Publication I August 8, 2019 A DNA-based biosensor assay for the kinetic characterization of ion-dependent aptamer folding and protein binding Therapeutic and diagnostic aptamers are nucleic acid oligomers designed to bind tightly and specifically...
Read full Article Publication I April 8, 2019 Specific inhibition of splicing factor activity by decoy RNA oligonucleotides Alternative splicing, a fundamental step in gene expression, is deregulated in many diseases. Splicing factors (SFs), which regulate this...
View Video Webinar I February 20, 2019 switchSENSE® – Biophysical Analysis with Electro-Switchable Biosurfaces Join us for this recorded webinar presentation to learn more about dynamicBIOSENSORS’ pioneering switchSENSE® sensor platform: an automated,...
Read App Note App Note I February 8, 2019 A new biosensor-based assay for aptamer-protein interaction analysis Here we show how aptamer-protein interactions can be analyzed with DNA-based biosensors. To this end, we study the salt-dependence and sequence and structure...
