Drugging the “undruggables”: PROTACs, dimerization, and more
Overcome the challenge of analyzing small-molecules, which inhibit or stabilize
protein-protein interactions (PPIs). Introducing the DNA Y-structure.
Screening PROTAC ternary complex formation using the novel FRET based switchSENSE® DNA Y-structure
Join us for this 30 min presentation held during our 2021 switchSENSE® user meeting and learn more about the Y-structure design and a PROTAC case study.
Have a look on how easy it is to immobilize E3 ligases and proteins of interest on the Y-structure: in this presentation we highlight the versatility of the Y-structure by screening a library of PROTACs against VHL, CRBN and BET proteins, resolving binary affinity and ternary interactions at the same time.
“At Merck, we see the switchSENSE® technology as a versatile and highly valuable tool to positively impact preclinical drug discovery projects. switchSENSE® has proven to be extremely helpful when it comes to the analysis of interactions between a drug candidate and its target protein.
Especially the formation of ternary complexes (DNA-Enzyme-Drug) and being able to detect the inhibition of the enzymatic activity is a big benefit. Moreover, we highly appreciate the support and the competence of the dynamicBIOSENSORS team.”
“switchSENSE® was a revelation: it solved a seemingly intractable antibody/antigen measurement with ease. The key was its remarkably versatile architecture, switchSENSE® seems only limited by the imagination of the researcher.“
“The architectures available from switchSENSE® are uniquely placed to offer us the flexibility and extraordinary sensitivity in our molecular interaction studies. This new technology will immediately open up a number of new research approaches, previously unattainable from existing technologies.“
→ Read more about what our customers say about us.
Find exemplary applications in life science research and drug discovery, for which switchSENSE® provides unique capabilites. Browse through publications, application notes, tutorials, and more.
Measure the kinetics and affinities of DNA/RNA binding proteins directly with switchSENSE®’s unique DNA nanolever approach.
Unravel the behaviour of complex binders like antibodies, PROTACs, and other ternary complexes with switchSENSE®’s versatile binding assays.
Conformation & Size
Solve the structure=function equation and study conformational changes in real-time with switchSENSE®’s dynamic measurement mode.
Discuss your specific needs with our specialists.