DISCOVER complex membrane targets: measure binding to GPCRs, ion channels and more directly on cells.

This is the fourth episode of our DISCOVER MOLECULAR INTERACTIONS webinar series. Each month we will talk about cutting-edge drug discovery topics like bispecific antibodies, PROTACs or small molecules targeting RNA. We will show you how to characterize the respective molecular interactions in depth, how to create assays with remarkable biological similarity, low sample consumption, high versatility and exceptional ease-of-use.
In this episode we will present Real-Time Interaction Cytometry ( RT-IC), a technology to measure real-time binding directly on living cells. Transmembrane proteins like GPCRs and ion channels often depend on their native environment and correct transmembrane domain folding in order to exert their functions. RT-IC enables you to measure interactions of molecules with these complex transmembrane targets in their native environment. That way you can be sure to study a functional protein and can avoid tedious isolation and refolding protocols. We will explain the basic principle of the technology as well as show example data for multivalent ligands binding to transmembrane receptors, GPCRs, and ion channels. If you are interested in another application, you can find all episodes of this webinar series here: