DISCOVER high throughput kinetic characterization of engineered multivalent peptide based inhibitors.

This is the seventh episode of our DISCOVER MOLECULAR INTERACTIONS webinar series. Each month we will talk about cutting-edge drug discovery topics like bispecific antibodies, PROTACs or small molecules targeting RNA. We will show you how to characterize the respective molecular interactions in depth, how to create assays with remarkable biological similarity, low sample consumption, high versatility and exceptional ease-of-use.
In this episode we are joined by our collaborator Clemens Schulte from the university of Würzburg. He is presenting his recent work on multivalent peptide-based effectors, which inhibit protein-protein interactions.switchSENSE^® was used to systematically evaluate the binding kinetics of more then 100 unique synthesized multivalent peptide binders and the results are compared to other biophysical methods like BLI. The influence of specific peptide architectures on binding dynamics was examined, which enabled the identification of highly inhibitory peptides.
If you are interested in another application, you can find all episodes of this webinar series here: