DISCOVER small molecule induced aptamer folding: a biosensor assay to detect structural changes.

This is the second episode of our DISCOVER MOLECULAR INTERACTIONS webinar series. Each month we will talk about cutting-edge drug discovery topics like bispecific antibodies, PROTACs or small molecules targeting RNA. We will show you how to characterize the respective molecular interactions in depth, how to create assays with remarkable biological similarity, low sample consumption, high versatility and exceptional ease-of-use.
In this second episode we will discuss aptamers and how small molecules can influence their 3D structure. We introduce a biosensor method to screen small molecules binding to nucleic acids. The presented assay provides not only precise kinetic rates of the interaction, but at the same time reveals binding-induced structural changes in the nucleic acids.
If you are interested in another application, you can find all episodes of this webinar series here: