Tutorial I April 23, 2021

heliX® Bivalent and Bispecific Binders Tutorial

Research continues to advance a growing number of bispecific binders for therapeutic purposes. These bivalent constructs that serve as molecular bridges to link together two binding moieties constitute a diverse class of macromolecules and can be found in many workflows, from induced-proximity platforms to those of the ever-expanding realm of biologics. ​ Please join us for this tutorial to see how our heliX® biosensor can be used to assay a broad range of bispecific analytes using the same workflow. Our automated solutions enable you to have full control over the surface-functionalization of your ligands, from density control, to dual antigen immobilization at pre-determined ratios. And with such control over the assay setup, you can evaluate features beyond target affinity, most notably ternary complex stability, impact of linker length on avidity binding, and target cell selectivity as a function of antigen abundance and spatial separation. ​ Using our powerful heliOS software, evaluate your readout to measure enhanced target engagement, and determining binding half-times for the affinity ranking of your bispecific analytes to their targets. ​ The Dynamic Biosensors team looks forward to hosting you and demonstrating the added value that switchSENSE® can bring to your work with bivalent and bispecific analytes!