We cover an array of various, different applications.
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Measure the kinetics and affinities of DNA/RNA binding proteins directly with switchSENSE®’s unique DNA nanolever approach.
Unravel the behaviour of complex binders like antibodies, PROTACs, and other ternary complexes with switchSENSE®’s versatile binding assays.
Conformation & Size
Solve the structure=function equation and study conformational changes in real-time with switchSENSE®’s dynamic measurement mode.
Bivalent and Bispecific Binders Tutorial
Join us for this tutorial to see how our heliX® biosensor can be used to assay a broad range of bispecific analytes using the same workflow. Our automated solutions enable you to have full control over the surface-functionalization of your ligands, from density control, to dual antigen immobilization at pre-determined ratios. And with such control over the assay setup, you can evaluate features beyond target affinity, most notably ternary complex stability, impact of linker length on avidity binding, and target cell selectivity as a function of antigen abundance and spatial separation.
Using our powerful heliOS software, evaluate your readout to measure enhanced target engagement, and determining binding half-times for the affinity ranking of your bispecific analytes to their targets.
Platform for in situ real-time measurement of protein-induced conformational changes of DNA
Switchable DNA interfaces for the highly sensitive detection of label-free DNA targets
Electrical Manipulation of DNA on Metal Surfaces
Controlling the surface density of DNA on gold by electrically induced desorption.
Dynamics of end grafted DNA molecules and possible biosensor applications
Electrical manipulation of oligonucleotides grafted to charged surfaces
The Role of Surface Charging during the Coadsorption of Mercaptohexanol to DNA Layers on Gold: Direct Observation of Desorption and Layer Reorientation
Dissimilar Kinetic Behavior of Electrically Manipulated Single- and Double-Stranded DNA Tethered to a Gold Surface
Dynamic Electrical Switching of DNA Layers on a Metal Surface
Structural Properties of Oligonucleotide Monolayers on Gold Surfaces Probed by Fluorescence Investigations
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