We cover an array of various, different applications.
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Measure the kinetics and affinities of DNA/RNA binding proteins directly with switchSENSE®’s unique DNA nanolever approach.
Unravel the behaviour of complex binders like antibodies, PROTACs, and other ternary complexes with switchSENSE®’s versatile binding assays.
Conformation & Size
Solve the structure=function equation and study conformational changes in real-time with switchSENSE®’s dynamic measurement mode.
Bivalent and Bispecific Binders Tutorial
Join us for this tutorial to see how our heliX® biosensor can be used to assay a broad range of bispecific analytes using the same workflow. Our automated solutions enable you to have full control over the surface-functionalization of your ligands, from density control, to dual antigen immobilization at pre-determined ratios. And with such control over the assay setup, you can evaluate features beyond target affinity, most notably ternary complex stability, impact of linker length on avidity binding, and target cell selectivity as a function of antigen abundance and spatial separation.
Using our powerful heliOS software, evaluate your readout to measure enhanced target engagement, and determining binding half-times for the affinity ranking of your bispecific analytes to their targets.
Covalent attachment of functionalized cardiolipin on a biosensor gold surface allows repetitive measurements of anticardiolipin antibodies in serum
Messung molekularer Interaktion mit dynamischen Oberflächensensoren
Sensing with electro-switchable biosurfaces
Quantitation of Affinity, Avidity, and Binding Kinetics of Protein Analytes with a Dynamically Switchable Biosurface
Conformations of End-Tethered DNA Molecules on Gold Surfaces: Influences of Applied Electric Potential, Electrolyte Screening, and Temperature
Platform for in situ real-time measurement of protein-induced conformational changes of DNA
Switchable DNA interfaces for the highly sensitive detection of label-free DNA targets
Electrical Manipulation of DNA on Metal Surfaces
Controlling the surface density of DNA on gold by electrically induced desorption.
Dynamics of end grafted DNA molecules and possible biosensor applications
Electrical manipulation of oligonucleotides grafted to charged surfaces
The Role of Surface Charging during the Coadsorption of Mercaptohexanol to DNA Layers on Gold: Direct Observation of Desorption and Layer Reorientation
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