switchSENSE®
eLearning Center
We cover an array of various, different applications.
Browse through publications, application notes,
tutorials, and more.
DNA/RNA Binders
Measure the kinetics and affinities of DNA/RNA binding proteins directly with switchSENSE®’s unique DNA nanolever approach.
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Multi-specific Binders
Unravel the behaviour of complex binders like antibodies, PROTACs, and other ternary complexes with switchSENSE®’s versatile binding assays.
Conformation & Size
Solve the structure=function equation and study conformational changes in real-time with switchSENSE®’s dynamic measurement mode.
HIGHLIGHTING
Bivalent and Bispecific Binders Tutorial
Join us for this tutorial to see how our heliX® biosensor can be used to assay a broad range of bispecific analytes using the same workflow. Our automated solutions enable you to have full control over the surface-functionalization of your ligands, from density control, to dual antigen immobilization at pre-determined ratios. And with such control over the assay setup, you can evaluate features beyond target affinity, most notably ternary complex stability, impact of linker length on avidity binding, and target cell selectivity as a function of antigen abundance and spatial separation.
Using our powerful heliOS software, evaluate your readout to measure enhanced target engagement, and determining binding half-times for the affinity ranking of your bispecific analytes to their targets.
Molecule Type
Analytical Method
A straightforward method to conjugate antibodies to oligonucleotides – preparation, purification and their applications
Quantifying DNA exonuclease activity
Binding theory: equations for affinity and kinetics analysis
Kinetic measurements and comparison with Biacore and solution data
Repeatability of binding kinetics measurements and regeneration performance
Association rate of two equimolar reactants in solution
List of protein hydrodynamic diameters
Real-time measurement of nickel ion chelation kinetics
Real-time measurements of DNA exonucleases
Characterization of a high-affinity anti-EPO antibody
Nanolever temperature stability standard DNA nanolever
Inhibitor induced shifts in the thermal stability of carbonic anhydrase
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