switchSENSE®

eLearning Center

We cover an array of various, different applications.
Browse through publications, application notes,
tutorials, and more.

DNA/RNA Binders

Measure the kinetics and affinities of DNA/RNA binding proteins directly with switchSENSE®’s unique DNA nanolever approach.

LEARN MORE

Multi-specific Binders

Unravel the behaviour of complex binders like antibodies, PROTACs, and other ternary complexes with switchSENSE®’s versatile binding assays.

Conformation & Size

Solve the structure=function equation and study conformational changes in real-time with switchSENSE®’s dynamic measurement mode.

LEARN MORE

HIGHLIGHTING

Bivalent and Bispecific Binders Tutorial

Join us for this tutorial to see how our heliX® biosensor can be used to assay a broad range of bispecific analytes using the same workflow. Our automated solutions enable you to have full control over the surface-functionalization of your ligands, from density control, to dual antigen immobilization at pre-determined ratios. And with such control over the assay setup, you can evaluate features beyond target affinity, most notably ternary complex stability, impact of linker length on avidity binding, and target cell selectivity as a function of antigen abundance and spatial separation. ​

Using our powerful heliOS software, evaluate your readout to measure enhanced target engagement, and determining binding half-times for the affinity ranking of your bispecific analytes to their targets. ​

Covalent attachment of functionalized cardiolipin on a biosensor gold surface allows repetitive measurements of anticardiolipin antibodies in serum

Covalent attachment of functionalized cardiolipin on a biosensor gold surface allows repetitive measurements of anticardiolipin antibodies in serum

Messung molekularer Interaktion mit dynamischen Oberflächensensoren

Messung molekularer Interaktion mit dynamischen Oberflächensensoren

Sensing with electro-switchable biosurfaces

Sensing with electro-switchable biosurfaces

Quantitation of Affinity, Avidity, and Binding Kinetics of Protein Analytes with a Dynamically Switchable Biosurface

Quantitation of Affinity, Avidity, and Binding Kinetics of Protein Analytes with a Dynamically Switchable Biosurface

Conformations of End-Tethered DNA Molecules on Gold Surfaces: Influences of Applied Electric Potential, Electrolyte Screening, and Temperature

Conformations of End-Tethered DNA Molecules on Gold Surfaces: Influences of Applied Electric Potential, Electrolyte Screening, and Temperature

Platform for in situ real-time measurement of protein-induced conformational changes of DNA

Platform for in situ real-time measurement of protein-induced conformational changes of DNA

Switchable DNA interfaces for the highly sensitive detection of label-free DNA targets

Switchable DNA interfaces for the highly sensitive detection of label-free DNA targets

Electrical Manipulation of DNA on Metal Surfaces

Electrical Manipulation of DNA on Metal Surfaces

Controlling the surface density of DNA on gold by electrically induced desorption.

Controlling the surface density of DNA on gold by electrically induced desorption.

Dynamics of end grafted DNA molecules and possible biosensor applications

Dynamics of end grafted DNA molecules and possible biosensor applications

Electrical manipulation of oligonucleotides grafted to charged surfaces

Electrical manipulation of oligonucleotides grafted to charged surfaces

The Role of Surface Charging during the Coadsorption of Mercaptohexanol to DNA Layers on Gold:  Direct Observation of Desorption and Layer Reorientation

The Role of Surface Charging during the Coadsorption of Mercaptohexanol to DNA Layers on Gold:  Direct Observation of Desorption and Layer Reorientation

Contact Us

Discuss your specific needs with our specialists.

info@dynamic-biosensors.com

+49 89 89 74 544-0

Lochhamer Str. 15, 82152 Martinsried/Planegg, Germany

M-F: 8am-5pm, S-S: Closed