switchSENSE® is a very versatile technology and offers comprehensive biophysical information. You can measure the following parameters:
Kinetics (association rate kon, dissociation rate koff)
Affinity, Avidity (Kd)
Dose response (EC, IC50)
Multispecific interactions (e.g. bispecific antibodies)
Ternary complex formation / proximity induced binding (e.g. PROTACs)
Conformational changes
Relative changes in protein size
Nucleic acid enzyme binding and activity (kcat, KM)
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General Questions