Read More App Note Biophysical Analysis of CRBN Variants in PROTAC Ternary Kinetics Proteolysis-targeting chimeras (PROTACs) and molecular glues have emerged as powerful therapeutic modalities by exploiting the ubiquitin–proteasome system to drive selective protein...
Read More App Note Real-time measurement of DNA polymerase activity and inhibition with switchSENSE® and the heliX® biosensor Polymerases play a key role in all living cells for the replication and preservation of genetic information. They are also interesting drug...
Read More App Note switchSENSE® Compatibility Sheet The switchSENSE® compatibility provides an overview on different conditions switchSENSE® measurements can be performed in. ...
Read App Note App Note I January 9, 2020 Site-specific covalent conjugation and purification of His-tagged proteins to DNA for switchSENSE® applications In this application note, we introduce a conjugation kit for a straightforward, site-selective and covalent...
Read App Note App Note I February 8, 2019 A new biosensor-based assay for aptamer-protein interaction analysis Here we show how aptamer-protein interactions can be analyzed with DNA-based biosensors. To this end, we study the salt-dependence and sequence and structure...
