Software

Plan, perform & analyze your experiments

switchANALYSIS

switchANALYSIS is a powerful software package designed for the rapid analysis and presentation of switchSENSE® data.

switchBUILD

switchBUILD software is an easy-to-use graphical planning tool to design and program experimental workflows.

switchCONTROL

switchCONTROL takes the simplicity of switchBUILD scripts and converts them into advanced commands for the unattended operation of the DRX instrument.

switchANALYSIS

switchANALYSIS is a powerful software package designed for the rapid analysis and presentation of switchSENSE® data. From single experiments to large complex datasets, the intuitive drag‘n‘drop format enables quick and efficient data interpretion. switchANALYSIS is fueled by advanced interaction and biophysical modelling providing publication ready graphs and full numerical packages available for export.

For installation a valid license key is required, please contact support@dynamic-biosensors.com for further information.

Download switchANALYSIS 1.7.0.34 (184 MB) >

Supplementary files
Download switchANALYSIS Sizing resources 1.0.0.16 (228 MB) >

Download earlier version >

NEW FEATURES

General Functionality
  • New storage of measurement files in switchANALYSIS files
  • Improved measurement handing process (see new experiment import)
New Experiment Import
  • Import experiment files to switchANALYSIS
  • Enabled drag-and-drop option to import experiment files
  • Imported files saved with the corresponding switchANALYSIS file
  • Share data and results by sharing the switchANALYSIS file
New Table View
  • View your data structured by Experiment, Assay and recommended Analysis
  • See additional information about your data, including biochip ID and flow rates
  • Adjust the table view to your needs, by adding or removing columns
  • Filter your measurements by color, ligand and more
  • Sort your measurements by electrode, flow rate and more
User Interface
  • New icons for all analyses
  • New tab icons to indicate Analysis type
  • New name for Overlay: Overview
  • New name for Molecular Ruler Analysis: Polymerase Activity Analysis
  • Improved selection of new Analyses with name labels
General Analyses
  • New view for additional information of each measurement
  • New functionality to create single color gradients for all plots
  • New functionality to create rainbow color gradient for all plots
Overview
  • New result type: Relative fluorescence
  • New line styles for all plots
  • New functionality to average Kinetics and Size data

NEW FEATURES

Kinetics Analysis
  • Newfunctionality for the automatic pairing of associations and dissociations
  • New functionality tocoupe amplitudes for Expert options
  • NewExpert options for Average Fits
  • New plot color selection in Individual Fits
Titration Analysis
  • New error bars for residuals
Sizing Analysis
  • New Sizing buffers TE40, HE40 and PE40
  • New automatic referencing
  • Improved Sizing accuracy
Polymerase Activity Analysis
  • New data normalization
  • New option to hide errorbars in secondary plots
  • Improved general data representation
Conformational Change Analysis
  • New option to hide errorbars
General Bugfixes
  • General Bugfixes

kON, kOFF, KD, IC50, DH, ΔDH, TM, ΔG, ΔH, ΔS, kCAT, KM, U

Sizing

 

Kinetics

 

Conformational Change

Advanced Interaction Analysis

  • Analyze kinetics from real-time association and measurements from simple 1:1 to complex interaction models and determine kinetic rate constants (kON, kOFF) and affinities/dissociation constants (KD) using individual and global fits.
  • Analyze equilibrium dissociation constants or IC50 values from titration curves using straightforward dose-response models, Langmuir, and Hill-fits.
  • Quantify avidity effects through the automated global analysis of measurements at different ligand densities.

 

Quantitative Biophysical Analysis

  • Measure and analyze protein diameters DH with Ångström accuracy and compare experimental data to hydrodynamic calculations from PDB files.
  • Quantify conformational changes ΔDin proteins by absolute numbers (diameter in nanometers) including monomers, dimers and multimers.
  • Monitor the enzymatic activity of polymerases and nucleases to determine catalytic rate constants (KCAT) and enzymatic units (U).
  • Evaluate melting curves of protein for thermal shift assays and the determination of melting points (TM).
  • Extract thermodynamic energies (ΔG, ΔH, ΔS) from integrated van‘t Hoff and Eyring analyses of temperature dependent measurements.

QUESTIONS?

Contact us – we are happy to help.

switchBUILD

switchBUILD software is an easy-to-use graphical planning tool to design and program experimental workflows.

  • Simply add individual assay elements including “kinetics”, “titration”, “sizing” and “melting” into the measurement queue to create your bespoke workflow.
  • Receive an optimized placement overview for all samples and auxiliary liquids required to run your experiment. Print your overview to take it to the lab and prepare your samples.

For installation a valid license key is required, please contact support@dynamic-biosensors.com for further information.

Download switchBUILD 1.10.0.32 (73,9 MB) >

Download earlier version >

NEW FEATURES

General Functionality
  • New Undo/Redo functionality
User Interface
  • New icons for all assays
  • New UI for all assays
  • Improved addition of assay elements
Chip Support
  • New support for ENZ-80-1 biochip
  • New automated detection of chip specific complementary DNA
Buffer Support
  • Improved custom buffers with modifiable names

NEW FEATURES

Maintenance Tools
  • New Reset tool: resets surface to double stranded unfunctionalized nanolevers
  • Enhanced Wash tool: wash channel with running buffer
  • Enhanced Standby tool: added surface passivation and chip status acquisition option
  • Enhanced Channel tool: added default passivation step
General Assays
  • New advanced options
  • New functionalization temperature control
  • New excitation power control
  • New analysis recommendation for measurements
  • Improved time prediction for all assays
  • Improved structures with conditional autosampler loops
  • Improved script structure with reusable script blocks
  • Improved script block names with better task description
Kinetics Assay
  • New support for concentration duplicates in Kinetics
  • New experimental setups for Capture Kinetics:
    • Biotin-Tag Capture
    • Streptavidin-Tag Capture
    • GFP-Tag Capture
    • GST-Tag Capture
  • Improved setup of Sandwich Format Assays
  • Improved simulation to better predict results
Sample Tracking
  • New ligand tracking to complement sample tracking
  • New tracking of Autosampler waste production
  • New tracking of Passivation solution consumption
  • Improved sample consumption tracking

QUESTIONS?

Contact us – we are happy to help.

switchCONTROL

switchCONTROL software takes the simplicity of switchBUILD scripts and converts them into advanced commands for the unattended operation of the DRX instrument.

For installation a valid license key is required, please contact support@dynamic-biosensors.com for further information.

Download switchCONTROL 1.4.20 (57 MB) >

Supplementary files

Download switchCONTROL_Supplementary (643 MB) >

QUESTIONS?

Contact us – we are happy to help.

senseMAKER

For planning your kinetic and titration experiments, you can use our free senseMAKER software.

This software is very intuitive and supports you in defining the right parameters and conditions for your experiments, regardless of which instrument you are using.

Download senseMAKER 1.1.0.9 (7 MB) > 

CONTACT US!
WE WILL GET IN TOUCH WITH YOU SHORTLY.

What are you interested in? *

Consumables & Reagents
Technical Support
Quotes & Orders

Instruments & Applications
Technical & Software Support
Assay Development

New to switchSENSE®
General Info & Evaluation
Purchasing

Dynamic Biosensors Data Privacy Policy

Contact Specialist