Software

Plan, perform & analyze your experiments

switchANALYSIS

switchANALYSIS is a powerful software package designed for the rapid analysis and presentation of switchSENSE® data.

switchBUILD

switchBUILD software is an easy-to-use graphical planning tool to design and program experimental workflows.

switchCONTROL

switchCONTROL takes the simplicity of switchBUILD scripts and converts them into advanced commands for the unattended operation of the DRX instrument.

switchANALYSIS

switchANALYSIS is a powerful software package designed for the rapid analysis and presentation of switchSENSE® data. From single experiments to large complex datasets, the intuitive drag‘n‘drop format enables quick and efficient data interpretion. switchANALYSIS is fueled by advanced interaction and biophysical modelling providing publication ready graphs and full numerical packages available for export.

For installation a valid license key is required, please contact support@dynamic-biosensors.com for further information.

Download switchANALYSIS 1.9.0.31 (205 MB) >

Supplementary files
Download switchANALYSIS Sizing resources 1.0.0.16 (228 MB) >

Download earlier version >

FEATURES
  • Replaced standard error of the mean with standard deviation as uncertainty for average Sizing results
PERFORMANCE
  • Improved loading time for files containing aligned and averaged datasets
  • Improved accuracy of Sizing fit algorithm
  • Improved default normalization level detection
  • Improved handling of auto-recovery file backups
BUG FIXES
  • Fixed incorrect fluorescence values on Voltage Response curves
  • Fixed ability to delete datasets from analysis which were still in use
  • Fixed missing config file after first installation
  • Fixed multiple sources of software crashes
  • Fixed incorrect Δt values in Polymerase fit
  • Fixed rare bug that would prevent setting normalization limits in Kinetics
  • Fixed incorrect Polymerase y-axis label
  • Fixed rare crash during save
  • Fixed error when loading file which contains references including x-offsets
  • Fixed incorrect behavior when fitting mixed static and dynamic mode data
  • Fixed rare case of time resolved measurement traces vanishing from plot
  • General bugfixes

kON, kOFF, KD, IC50, DH, ΔDH, TM, ΔG, ΔH, ΔS, kCAT, KM, U

Sizing

 

Kinetics

 

Conformational Change

Advanced Interaction Analysis

  • Analyze kinetics from real-time association and measurements from simple 1:1 to complex interaction models and determine kinetic rate constants (kON, kOFF) and affinities/dissociation constants (KD) using individual and global fits.
  • Analyze equilibrium dissociation constants or IC50 values from titration curves using straightforward dose-response models, Langmuir, and Hill-fits.
  • Quantify avidity effects through the automated global analysis of measurements at different ligand densities.

 

Quantitative Biophysical Analysis

  • Measure and analyze protein diameters DH with Ångström accuracy and compare experimental data to hydrodynamic calculations from PDB files.
  • Quantify conformational changes ΔDin proteins by absolute numbers (diameter in nanometers) including monomers, dimers and multimers.
  • Monitor the enzymatic activity of polymerases and nucleases to determine catalytic rate constants (KCAT) and enzymatic units (U).
  • Evaluate melting curves of protein for thermal shift assays and the determination of melting points (TM).
  • Extract thermodynamic energies (ΔG, ΔH, ΔS) from integrated van‘t Hoff and Eyring analyses of temperature dependent measurements.

QUESTIONS?

Contact us – we are happy to help.

switchBUILD

switchBUILD software is an easy-to-use graphical planning tool to design and program experimental workflows.

  • Simply add individual assay elements including “kinetics”, “titration”, “sizing” and “melting” into the measurement queue to create your bespoke workflow.
  • Receive an optimized placement overview for all samples and auxiliary liquids required to run your experiment. Print your overview to take it to the lab and prepare your samples.

For installation a valid license key is required, please contact support@dynamic-biosensors.com for further information.

Download switchBUILD 1.12.0.21 (74,7 MB) >

Download earlier version >

FEATURES
  • New One-Shot Kinetics as default Kinetics assay
  • Added support for special characters in assay and tool names
  • Added information about reference DNA to ligand samples
  • Added required buffer and aux volumes to Autosampler
  • Added ability to run repeated concentration series in a Titration or Kinetics assay
  • Added support for sample rates up to 20 Hz
IMPROVEMENTS
  • Improved passivation script to reduce time from 10 to 5 minutes
  • Improved placement of capture samples in autosampler
  • Improved autosampler pdf export style
BUG FIXES
  • Fixed rare case that would prevent deselecting the main electrode in a Kinetics assay
  • Fixed ligand names resetting when changing chip
  • Fixed concentration dependent incubation times calculation in Titration
  • Fixed overwriting of LED power levels in all assays
  • Fixed incorrect capture limits for experiment temperature unequal to 25°C
  • Fixed rare crash when clicking on autosampler vial details
  • Fixed bug that caused time to show 0:00 in capture kinetics
  • Fixed incorrect behavior when selecting only association blank in one-shot kinetics
  • Fixed rare bug which would prevent using fluorescence only stopped flow in Melting assay
  • Fixed crash when entering kOFF values greater than 1
  • Fixed rare crash when changing running buffer while having a wash step with running buffer in the assay

This version of switchBUILD is only compatible with switchCONTROL 1.6.0 or newer

QUESTIONS?

Contact us – we are happy to help.

switchCONTROL

switchCONTROL software takes the simplicity of switchBUILD scripts and converts them into advanced commands for the unattended operation of the DRX instrument.

For installation a valid license key is required, please contact support@dynamic-biosensors.com for further information.

Download switchCONTROL 1.6.23 (56,5 MB) >

Supplementary files
Download switchCONTROL_Supplementary (643 MB) >

FEATURES
  • New projects field under script name adds project name to data folders
  • New Autosampler loop with support for repeated samples and custom ordering
  • New sleep state after clean & sleep which enforces wake up & prime to ensure correct fluidics state before running any experiment
  • Simplified installation of switchCONTROL on computers not connected to a DRX for easy script design
IMPROVEMENTS
  • Increased live plot size
  • Improved default zoom level for plots
  • Improved chip status by reducing time to
  • Improved prime, clean & sleep and clean & start (new wake up & prime) scripts to be more time efficient
BUG FIXES
  • Fixed error message symbol remaining active more than 30 minutes

QUESTIONS?

Contact us – we are happy to help.

senseMAKER

For planning your kinetic and titration experiments, you can use our free senseMAKER software.

This software is very intuitive and supports you in defining the right parameters and conditions for your experiments, regardless of which instrument you are using.

Download senseMAKER 1.1.0.9 (7 MB) > 

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