RESEARCH TECHNOLOGY ADVANCES
Scientists work at the frontiers of knowledge. In order to increase the insights into molecular interactions and disease mechanisms and to discover new therapeutic options, they need cutting-edge, innovative tools.
The list of methodologies is ever-growing as scientists push back the boundaries of what is possible and create new experimental approaches, for example DNA nanostructures, CRISPR-Cas9 gene editing, or advanced imaging technologies.
The switchSENSE® technology is helping scientists to tackle the most difficult questions and to expand the scientific toolbox.
You can use any of our versatile applications to establish, optimize and validate new experimental technologies,
→ Nucleic acid binders
→ High-performance kinetic assays
→ Multispecific binders
→ Ternary interactions
→ DNA nanotechnology
→ Cell-based kinetic assays
→ Highly shape- and size-tunable membrane nanopores made with DNA
2022 I Nature Nanotechnology (open access)
→ The role of DNA nanostructures in the catalytic properties of an allosterically regulated protease
2022 I Science Advances (open access)
→ Triazine-Modified 7-Deaza-2′-deoxyadenosines: Better Suited for Bioorthogonal Labeling of DNA by PCR than 2′-Deoxyuridines
2019 I Bioconjugate Chemistry
→ Magnesium-Dependent Electrical Actuation and Stability of DNA Origami Rods
2018 I ACS Appl. Mater. Interfaces
→ Electrical Actuation of a DNA Origami Nanolever on an Electrode
2017 I Journal of the American Chemical Society
→ Mapping the sugar dependency for rational generation of a DNA-RNA hybrid-guided Cas9 endonuclease
2017 I Nature Communications (open access)
→ Resolving Binding Events on the Multifunctional Human Serum Albumin
2020 I ChemMedChem (open access)
Discuss your specific needs with our specialists.