We cover an array of various, different applications.
Browse through publications, application notes,
tutorials, and more.
Measure the kinetics and affinities of DNA/RNA binding proteins directly with switchSENSE®’s unique DNA nanolever approach.
Antibodies / Bispecifics
Unravel the behaviour of complex binders like antibodies and other bispecifics with switchSENSE®’s versatile binding assays.
Conformation & Size
Solve the structure=function equation and study conformational changes in real-time with switchSENSE®’s dynamic measurement mode.
Multiplex DNA-Binder Tutorial
In this 20 min tutorial, learn how easy it is to measure kinetics of a DNA-binding protein to 4 targets simultaneously with our new heliX® biosensor.
We are analyzing association and dissociation rates, and KD values to understand how changes in a target DNA sequence, the T7 promoter, affect T7 RNA polymerase binding kinetics. Watch the video to learn how heliX® enables you to multiplex your molecular interaction studies in a user friendly, cost effective, and reproducible way.
switchSENSE Compatibility Sheet
Mapping the sugar dependency for rational generation of a DNA-RNA hybrid-guided Cas9 endonuclease
Physical interaction between the strawberry allergen Fra a 1 and an associated partner FaAP: Interaction of Fra a 1 proteins and FaAP.
Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy I Paper
Structural study of the Fox-1 RRM protein hydration reveals a role for key water molecules in RRM-RNA recognition.
Advanced biophysical analysis of mono and bispecific antibody formats
Biophysical analysis of liposomes and antibody-receptor interactions on VLPs
Biophysical analysis of Cas9-DNA interactions and enzymatic activity
Hydrodynamic diameter and thermal stability measurements of protein kinase A
switchSENSE: A new technology to study protein-RNA interactions
Molecular mechanism governing ratio-dependent transcription regulation in the ccdAB operon.
The long zinc finger domain of PRDM9 forms a highly stable and long-lived complex with its DNA recognition sequence.
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