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Measure the kinetics and affinities of DNA/RNA binding proteins directly with switchSENSE®’s unique DNA nanolever approach.
Unravel the behaviour of complex binders like antibodies, PROTACs, and other ternary complexes with switchSENSE®’s versatile binding assays.
Conformation & Size
Solve the structure=function equation and study conformational changes in real-time with switchSENSE®’s dynamic measurement mode.
Bivalent and Bispecific Binders Tutorial
Join us for this tutorial to see how our heliX® biosensor can be used to assay a broad range of bispecific analytes using the same workflow. Our automated solutions enable you to have full control over the surface-functionalization of your ligands, from density control, to dual antigen immobilization at pre-determined ratios. And with such control over the assay setup, you can evaluate features beyond target affinity, most notably ternary complex stability, impact of linker length on avidity binding, and target cell selectivity as a function of antigen abundance and spatial separation.
Using our powerful heliOS software, evaluate your readout to measure enhanced target engagement, and determining binding half-times for the affinity ranking of your bispecific analytes to their targets.
Physical interaction between the strawberry allergen Fra a 1 and an associated partner FaAP: Interaction of Fra a 1 proteins and FaAP.
Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy I Paper
Structural study of the Fox-1 RRM protein hydration reveals a role for key water molecules in RRM-RNA recognition.
Advanced biophysical analysis of mono and bispecific antibody formats
Biophysical analysis of liposomes and antibody-receptor interactions on VLPs
Biophysical analysis of Cas9-DNA interactions and enzymatic activity
Hydrodynamic diameter and thermal stability measurements of protein kinase A
switchSENSE: A new technology to study protein-RNA interactions
Molecular mechanism governing ratio-dependent transcription regulation in the ccdAB operon.
The long zinc finger domain of PRDM9 forms a highly stable and long-lived complex with its DNA recognition sequence.
Specialized interfaces of Smc5/6 control hinge stability and DNA association
Molecular dynamics of DNA–protein conjugates
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