switchSENSE®

eLearning Center

We cover an array of various, different applications.
Browse through publications, application notes,
tutorials, and more.

DNA/RNA Binders

Measure the kinetics and affinities of DNA/RNA binding proteins directly with switchSENSE®’s unique DNA nanolever approach.

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Multi-specific Binders

Unravel the behaviour of complex binders like antibodies, PROTACs, and other ternary complexes with switchSENSE®’s versatile binding assays.

Conformation & Size

Solve the structure=function equation and study conformational changes in real-time with switchSENSE®’s dynamic measurement mode.

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HIGHLIGHTING

Bivalent and Bispecific Binders Tutorial

Join us for this tutorial to see how our heliX® biosensor can be used to assay a broad range of bispecific analytes using the same workflow. Our automated solutions enable you to have full control over the surface-functionalization of your ligands, from density control, to dual antigen immobilization at pre-determined ratios. And with such control over the assay setup, you can evaluate features beyond target affinity, most notably ternary complex stability, impact of linker length on avidity binding, and target cell selectivity as a function of antigen abundance and spatial separation. ​

Using our powerful heliOS software, evaluate your readout to measure enhanced target engagement, and determining binding half-times for the affinity ranking of your bispecific analytes to their targets. ​

A straightforward method to conjugate antibodies to oligonucleotides – preparation, purification and their applications

A straightforward method to conjugate antibodies to oligonucleotides – preparation, purification and their applications

Binding theory: equations for affinity and kinetics analysis

Binding theory: equations for affinity and kinetics analysis

Kinetic measurements and comparison with Biacore and solution data

Kinetic measurements and comparison with Biacore and solution data

Repeatability of binding kinetics measurements and regeneration performance

Repeatability of binding kinetics measurements and regeneration performance

Association rate of two equimolar reactants in solution

Association rate of two equimolar reactants in solution

Real-time measurement of nickel ion chelation kinetics

Real-time measurement of nickel ion chelation kinetics

Real-time measurements of DNA exonucleases

Real-time measurements of DNA exonucleases

Characterization of a high-affinity anti-EPO antibody

Characterization of a high-affinity anti-EPO antibody

Nanolever temperature stability standard DNA nanolever

Nanolever temperature stability standard DNA nanolever

Inhibitor induced shifts in the thermal stability of carbonic anhydrase

Inhibitor induced shifts in the thermal stability of carbonic anhydrase

Contact Us

Discuss your specific needs with our specialists.

info@dynamic-biosensors.com

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