switchSENSE®

eLearning Center

We cover an array of various, different applications.
Browse through publications, application notes,
tutorials, and more.

DNA/RNA Binders

Measure the kinetics and affinities of DNA/RNA binding proteins directly with switchSENSE®’s unique DNA nanolever approach.

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Multi-specific Binders

Unravel the behaviour of complex binders like antibodies, PROTACs, and other ternary complexes with switchSENSE®’s versatile binding assays.

Conformation & Size

Solve the structure=function equation and study conformational changes in real-time with switchSENSE®’s dynamic measurement mode.

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HIGHLIGHTING

Bivalent and Bispecific Binders Tutorial

Join us for this tutorial to see how our heliX® biosensor can be used to assay a broad range of bispecific analytes using the same workflow. Our automated solutions enable you to have full control over the surface-functionalization of your ligands, from density control, to dual antigen immobilization at pre-determined ratios. And with such control over the assay setup, you can evaluate features beyond target affinity, most notably ternary complex stability, impact of linker length on avidity binding, and target cell selectivity as a function of antigen abundance and spatial separation. ​

Using our powerful heliOS software, evaluate your readout to measure enhanced target engagement, and determining binding half-times for the affinity ranking of your bispecific analytes to their targets. ​

Biophysical analysis of liposomes and antibody-receptor interactions on VLPs

Biophysical analysis of liposomes and antibody-receptor interactions on VLPs

Biophysical analysis of Cas9-DNA interactions and enzymatic activity

Biophysical analysis of Cas9-DNA interactions and enzymatic activity

Hydrodynamic diameter and thermal stability measurements of protein kinase A

Hydrodynamic diameter and thermal stability measurements of protein kinase A

switchSENSE: A new technology to study protein-RNA interactions

switchSENSE: A new technology to study protein-RNA interactions

Molecular mechanism governing ratio-dependent transcription regulation in the ccdAB operon.

Molecular mechanism governing ratio-dependent transcription regulation in the ccdAB operon.

The long zinc finger domain of PRDM9 forms a highly stable and long-lived complex with its DNA recognition sequence.

The long zinc finger domain of PRDM9 forms a highly stable and long-lived complex with its DNA recognition sequence.

Specialized interfaces of Smc5/6 control hinge stability and DNA association

Specialized interfaces of Smc5/6 control hinge stability and DNA association

Molecular dynamics of DNA–protein conjugates

Molecular dynamics of DNA–protein conjugates

Detection of the carcinogenic water pollutant Benzo[a]pyrene

Detection of the carcinogenic water pollutant Benzo[a]pyrene

Protein analysis by time-resolved measurements

Protein analysis by time-resolved measurements

Polymerase/DNA interactions and enzymatic activity

Polymerase/DNA interactions and enzymatic activity

switchSENSE® for characterization of polymerases

switchSENSE® for characterization of polymerases

Contact Us

Discuss your specific needs with our specialists.

info@dynamic-biosensors.com

+49 89 89 74 544-0

Lochhamer Str. 15, 82152 Martinsried/Planegg, Germany

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