switchSENSE®
eLearning Center
We cover an array of various, different applications.
Browse through publications, application notes,
tutorials, and more.
DNA/RNA Binders
Measure the kinetics and affinities of DNA/RNA binding proteins directly with switchSENSE®’s unique DNA nanolever approach.
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Multi-specific Binders
Unravel the behaviour of complex binders like antibodies, PROTACs, and other ternary complexes with switchSENSE®’s versatile binding assays.
Conformation & Size
Solve the structure=function equation and study conformational changes in real-time with switchSENSE®’s dynamic measurement mode.
HIGHLIGHTING
Bivalent and Bispecific Binders Tutorial
Join us for this tutorial to see how our heliX® biosensor can be used to assay a broad range of bispecific analytes using the same workflow. Our automated solutions enable you to have full control over the surface-functionalization of your ligands, from density control, to dual antigen immobilization at pre-determined ratios. And with such control over the assay setup, you can evaluate features beyond target affinity, most notably ternary complex stability, impact of linker length on avidity binding, and target cell selectivity as a function of antigen abundance and spatial separation.
Using our powerful heliOS software, evaluate your readout to measure enhanced target engagement, and determining binding half-times for the affinity ranking of your bispecific analytes to their targets.
Molecule Type
Analytical Method
switchSENSE® Dynamic Response Sensing
switchSENSE® Fluorescence Proximity Sensing – in static mode
XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining
switchSENSE® Analysis of Protein Diameters and Conformational Changes
Assembly and Characterization of a Slingshot DNA Nanostructure for the Analysis of Bivalent and Bispecific Analytes with Biosensors
DNA Primer Extension with Cyclopropenylated 7-Deaza-2′-deoxyadenosine and Efficient Bioorthogonal Labeling in Vitro and in Living Cells
Fungal Glutathione Transferases as Tools to Explore the Chemical Diversity of Amazonian Wood Extractives
mRNA Deadenylation Is Coupled to Translation Rates by the Differential Activities of Ccr4-Not Nucleases
ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase
Electrical actuation of a DNA origami nanolever on an electrode
Preclinical Development of a Novel, Orally-Administered Anti-Tumour Necrosis Factor Domain Antibody for the Treatment of Inflammatory Bowel Disease
High-affinity capturing of tagged proteins on the switchSENSE® biochip using Strep-Tactin®XT
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