We cover an array of various, different applications.
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Measure the kinetics and affinities of DNA/RNA binding proteins directly with switchSENSE®’s unique DNA nanolever approach.
Unravel the behaviour of complex binders like antibodies, PROTACs, and other ternary complexes with switchSENSE®’s versatile binding assays.
Conformation & Size
Solve the structure=function equation and study conformational changes in real-time with switchSENSE®’s dynamic measurement mode.
Bivalent and Bispecific Binders Tutorial
Join us for this tutorial to see how our heliX® biosensor can be used to assay a broad range of bispecific analytes using the same workflow. Our automated solutions enable you to have full control over the surface-functionalization of your ligands, from density control, to dual antigen immobilization at pre-determined ratios. And with such control over the assay setup, you can evaluate features beyond target affinity, most notably ternary complex stability, impact of linker length on avidity binding, and target cell selectivity as a function of antigen abundance and spatial separation.
Using our powerful heliOS software, evaluate your readout to measure enhanced target engagement, and determining binding half-times for the affinity ranking of your bispecific analytes to their targets.
mRNA Deadenylation Is Coupled to Translation Rates by the Differential Activities of Ccr4-Not Nucleases
ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase
Electrical actuation of a DNA origami nanolever on an electrode
Preclinical Development of a Novel, Orally-Administered Anti-Tumour Necrosis Factor Domain Antibody for the Treatment of Inflammatory Bowel Disease
High-affinity capturing of tagged proteins on the switchSENSE® biochip using Strep-Tactin®XT
A low-complexity region in the YTH domain protein Mmi1 enhances RNA binding
switchSENSE Compatibility Sheet
Mapping the sugar dependency for rational generation of a DNA-RNA hybrid-guided Cas9 endonuclease
Physical interaction between the strawberry allergen Fra a 1 and an associated partner FaAP: Interaction of Fra a 1 proteins and FaAP.
Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy I Paper
Structural study of the Fox-1 RRM protein hydration reveals a role for key water molecules in RRM-RNA recognition.
Advanced biophysical analysis of mono and bispecific antibody formats
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