We cover an array of various, different applications.
Browse through publications, application notes,
tutorials, and more.
Measure the kinetics and affinities of DNA/RNA binding proteins directly with switchSENSE®’s unique DNA nanolever approach.
Antibodies / Bispecifics
Unravel the behaviour of complex binders like antibodies and other bispecifics with switchSENSE®’s versatile binding assays.
Conformation & Size
Solve the structure=function equation and study conformational changes in real-time with switchSENSE®’s dynamic measurement mode.
Multiplex DNA-Binder Tutorial
In this 20 min tutorial, learn how easy it is to measure kinetics of a DNA-binding protein to 4 targets simultaneously with our new heliX® biosensor.
We are analyzing association and dissociation rates, and KD values to understand how changes in a target DNA sequence, the T7 promoter, affect T7 RNA polymerase binding kinetics. Watch the video to learn how heliX® enables you to multiplex your molecular interaction studies in a user friendly, cost effective, and reproducible way.
Site-specific covalent conjugation and purification of His-tagged proteins to DNA for switchSENSE® applications I App Note
heliX® line of biosensor instruments
CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells I Paper
A DNA-based biosensor assay for the kinetic characterization of ion-dependent aptamer folding and protein binding I Publication
Triazine-Modified 7-Deaza-2′-deoxyadenosines: Better Suited for Bioorthogonal Labeling of DNA by PCR than 2′-Deoxyuridines
Magnesium-Dependent Electrical Actuation and Stability of DNA Origami Rods
FOXP2 Oligomerization and DNA Binding
Tailored peptide phenyl esters block ClpXP proteolysis by an unusual breakdown into a heptamer‐hexamer assembly
switchSENSE® – Biophysical Analysis with Electro-Switchable Biosurfaces
A new biosensor-based assay for aptamer-protein interaction analysis I App Note
High-affinity capturing of antibodies on the switchSENSE® biochip using CaptureSelect™ affinity ligands
Utilization of Staphylococcal Immune Evasion Protein Sbi as a Novel Vaccine Adjuvant
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