We cover an array of various, different applications.
Browse through publications, application notes,
tutorials, and more.
Measure the kinetics and affinities of DNA/RNA binding proteins directly with switchSENSE®’s unique DNA nanolever approach.
Unravel the behaviour of complex binders like antibodies, PROTACs, and other ternary complexes with switchSENSE®’s versatile binding assays.
Conformation & Size
Solve the structure=function equation and study conformational changes in real-time with switchSENSE®’s dynamic measurement mode.
Bivalent and Bispecific Binders Tutorial
Join us for this tutorial to see how our heliX® biosensor can be used to assay a broad range of bispecific analytes using the same workflow. Our automated solutions enable you to have full control over the surface-functionalization of your ligands, from density control, to dual antigen immobilization at pre-determined ratios. And with such control over the assay setup, you can evaluate features beyond target affinity, most notably ternary complex stability, impact of linker length on avidity binding, and target cell selectivity as a function of antigen abundance and spatial separation.
Using our powerful heliOS software, evaluate your readout to measure enhanced target engagement, and determining binding half-times for the affinity ranking of your bispecific analytes to their targets.
The trimer to monomer transition of Tumor Necrosis Factor-Alpha is a dynamic process that is significantly altered by therapeutic antibodies
Single-Molecule Sensing of DNA Intercalating Drugs in Water
An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2
Preparation of single- and double-oligonucleotide antibody conjugates and their application for protein analytics
Validation of the Slow Off-Kinetics of Sirtuin-Rearranging Ligands (SirReals) by Means of Label-Free Electrically Switchable Nanolever Technology
Site-specific covalent conjugation and purification of His-tagged proteins to DNA for switchSENSE® applications I App Note
heliX® line of biosensor instruments
CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells I Paper
A DNA-based biosensor assay for the kinetic characterization of ion-dependent aptamer folding and protein binding I Publication
Triazine-Modified 7-Deaza-2′-deoxyadenosines: Better Suited for Bioorthogonal Labeling of DNA by PCR than 2′-Deoxyuridines
Magnesium-Dependent Electrical Actuation and Stability of DNA Origami Rods
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