switchSENSE®
eLearning Center
We cover an array of various, different applications.
Browse through publications, application notes,
tutorials, and more.
DNA/RNA Binders
Measure the kinetics and affinities of DNA/RNA binding proteins directly with switchSENSE®’s unique DNA nanolever approach.
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Antibodies / Bispecifics
Unravel the behaviour of complex binders like antibodies and other bispecifics with switchSENSE®’s versatile binding assays.
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Conformation & Size
Solve the structure=function equation and study conformational changes in real-time with switchSENSE®’s dynamic measurement mode.
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HIGHLIGHTING
Multiplex DNA-Binder Tutorial
In this 20 min tutorial, learn how easy it is to measure kinetics of a DNA-binding protein to 4 targets simultaneously with our new heliX® biosensor.
We are analyzing association and dissociation rates, and KD values to understand how changes in a target DNA sequence, the T7 promoter, affect T7 RNA polymerase binding kinetics. Watch the video to learn how heliX® enables you to multiplex your molecular interaction studies in a user friendly, cost effective, and reproducible way.
Molecule Type
Analytical Method
Reverse Transcriptase binding and activity assays with switchSENSE®
RNA-binding proteins distinguish between similar sequence motifs to promote targeted deadenylation by Ccr4-Not
Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus
Bifunctional biosensors for the analysis of bispecific antibodies
Biophysical characterization of bispecific antibodies developed for enhancement of dual-targeting specificity with switchSENSE®
Measuring ligation activity of T4 DNA ligase on nicked DNA with switchSENSE®
Sizing Analysis of the Ubiquitin / E1-E2-E3 Complex using switchSENSE® technology
Structural and Kinetic Profiling of Allosteric Modulation of Duplex DNA Induced by DNA-Binding Polyamide Analogues
switchSENSE® Bispecific Antibodies
switchSENSE® Antibody Sensing
switchSENSE® Protein Size. Different Size = Different Switching Speed
switchSENSE® Conformational Changes
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