We cover an array of various, different applications.
Browse through publications, application notes,
tutorials, and more.
Measure the kinetics and affinities of DNA/RNA binding proteins directly with switchSENSE®’s unique DNA nanolever approach.
Unravel the behaviour of complex binders like antibodies, PROTACs, and other ternary complexes with switchSENSE®’s versatile binding assays.
Conformation & Size
Solve the structure=function equation and study conformational changes in real-time with switchSENSE®’s dynamic measurement mode.
Bivalent and Bispecific Binders Tutorial
Join us for this tutorial to see how our heliX® biosensor can be used to assay a broad range of bispecific analytes using the same workflow. Our automated solutions enable you to have full control over the surface-functionalization of your ligands, from density control, to dual antigen immobilization at pre-determined ratios. And with such control over the assay setup, you can evaluate features beyond target affinity, most notably ternary complex stability, impact of linker length on avidity binding, and target cell selectivity as a function of antigen abundance and spatial separation.
Using our powerful heliOS software, evaluate your readout to measure enhanced target engagement, and determining binding half-times for the affinity ranking of your bispecific analytes to their targets.
Sizing Analysis of the Ubiquitin / E1-E2-E3 Complex using switchSENSE® technology
Structural and Kinetic Profiling of Allosteric Modulation of Duplex DNA Induced by DNA-Binding Polyamide Analogues
switchSENSE® Bispecific Antibodies
switchSENSE® Antibody Sensing
switchSENSE® Protein Size. Different Size = Different Switching Speed
switchSENSE® Conformational Changes
switchSENSE® Dynamic Response Sensing
switchSENSE® Fluorescence Proximity Sensing – in static mode
XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining
switchSENSE® Analysis of Protein Diameters and Conformational Changes
Assembly and Characterization of a Slingshot DNA Nanostructure for the Analysis of Bivalent and Bispecific Analytes with Biosensors
DNA Primer Extension with Cyclopropenylated 7-Deaza-2′-deoxyadenosine and Efficient Bioorthogonal Labeling in Vitro and in Living Cells
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