We cover an array of various, different applications.
Browse through publications, application notes,
tutorials, and more.
Measure the kinetics and affinities of DNA/RNA binding proteins directly with switchSENSE®’s unique DNA nanolever approach.
Antibodies / Bispecifics
Unravel the behaviour of complex binders like antibodies and other bispecifics with switchSENSE®’s versatile binding assays.
Conformation & Size
Solve the structure=function equation and study conformational changes in real-time with switchSENSE®’s dynamic measurement mode.
Multiplex DNA-Binder Tutorial
In this 20 min tutorial, learn how easy it is to measure kinetics of a DNA-binding protein to 4 targets simultaneously with our new heliX® biosensor.
We are analyzing association and dissociation rates, and KD values to understand how changes in a target DNA sequence, the T7 promoter, affect T7 RNA polymerase binding kinetics. Watch the video to learn how heliX® enables you to multiplex your molecular interaction studies in a user friendly, cost effective, and reproducible way.
switchSENSE® Dynamic Response Sensing
switchSENSE® Fluorescence Proximity Sensing – in static mode
XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining
switchSENSE® Analysis of Protein Diameters and Conformational Changes
Assembly and Characterization of a Slingshot DNA Nanostructure for the Analysis of Bivalent and Bispecific Analytes with Biosensors
DNA Primer Extension with Cyclopropenylated 7-Deaza-2′-deoxyadenosine and Efficient Bioorthogonal Labeling in Vitro and in Living Cells
mRNA Deadenylation Is Coupled to Translation Rates by the Differential Activities of Ccr4-Not Nucleases
ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase
Electrical actuation of a DNA origami nanolever on an electrode
Preclinical Development of a Novel, Orally-Administered Anti-Tumour Necrosis Factor Domain Antibody for the Treatment of Inflammatory Bowel Disease
High-affinity capturing of tagged proteins on the switchSENSE® biochip using Strep-Tactin®XT
A low-complexity region in the YTH domain protein Mmi1 enhances RNA binding
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