switchSENSE®

eLearning Center

We cover an array of various, different applications.
Browse through publications, application notes,
tutorials, and more.

DNA/RNA Binders

Measure the kinetics and affinities of DNA/RNA binding proteins directly with switchSENSE®’s unique DNA nanolever approach.

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Multi-specific Binders

Unravel the behaviour of complex binders like antibodies, PROTACs, and other ternary complexes with switchSENSE®’s versatile binding assays.

Conformation & Size

Solve the structure=function equation and study conformational changes in real-time with switchSENSE®’s dynamic measurement mode.

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HIGHLIGHTING

Bivalent and Bispecific Binders Tutorial

Join us for this tutorial to see how our heliX® biosensor can be used to assay a broad range of bispecific analytes using the same workflow. Our automated solutions enable you to have full control over the surface-functionalization of your ligands, from density control, to dual antigen immobilization at pre-determined ratios. And with such control over the assay setup, you can evaluate features beyond target affinity, most notably ternary complex stability, impact of linker length on avidity binding, and target cell selectivity as a function of antigen abundance and spatial separation. ​

Using our powerful heliOS software, evaluate your readout to measure enhanced target engagement, and determining binding half-times for the affinity ranking of your bispecific analytes to their targets. ​

Sizing Analysis of the Ubiquitin / E1-E2-E3 Complex using switchSENSE® technology

Sizing Analysis of the Ubiquitin / E1-E2-E3 Complex using switchSENSE® technology

Structural and Kinetic Profiling of Allosteric Modulation of Duplex DNA Induced by DNA-Binding Polyamide Analogues

Structural and Kinetic Profiling of Allosteric Modulation of Duplex DNA Induced by DNA-Binding Polyamide Analogues

switchSENSE® Protein Size. Different Size = Different Switching Speed

switchSENSE® Protein Size. Different Size = Different Switching Speed

switchSENSE® Fluorescence Proximity Sensing – in static mode

switchSENSE® Fluorescence Proximity Sensing – in static mode

XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining

XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining

switchSENSE® Analysis of Protein Diameters and Conformational Changes

switchSENSE® Analysis of Protein Diameters and Conformational Changes

Assembly and Characterization of a Slingshot DNA Nanostructure for the Analysis of Bivalent and Bispecific Analytes with Biosensors

Assembly and Characterization of a Slingshot DNA Nanostructure for the Analysis of Bivalent and Bispecific Analytes with Biosensors

DNA Primer Extension with Cyclopropenylated 7-Deaza-2′-deoxyadenosine and Efficient Bioorthogonal Labeling in Vitro and in Living Cells

DNA Primer Extension with Cyclopropenylated 7-Deaza-2′-deoxyadenosine and Efficient Bioorthogonal Labeling in Vitro and in Living Cells

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info@dynamic-biosensors.com

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