Cancer immune evasion is one of the emerging hallmarks of cancer and ever since its observation, researchers try to use it to their advantage in order to create new therapeutic possibilities. Immunotherapies aim at boosting the immune system’s capacity to fight the disease. Common approaches of immunotherapy are:
→ Immune checkpoint inhibitors
Immune checkpoints are important constituents of the immune system that avoid an overshooting immune reaction and are thus important to prevent chronic inflammation or autoimmunity. Immune cells like T lymphocytes express immune checkpoint receptors and upon binding of their respective ligand the cells are suppressed. Cancer cells exploit this regulatory mechanism by expressing high levels of immune checkpoint ligands, thereby suppressing the anti-tumour immune response. Immune checkpoint inhibitors block the activation of immune checkpoint receptors to sustain immune cell activity against malignant cells.
→ T-cell transfer
T-cells are part of the adaptive immune system and can mount a potent immune response against cancers. To improve their efficacy, they can be isolated from the tumour, the most active cells can be selected and expanded and finally infused back into the patient. New innovative T-cell-based therapies have recently been developed, where T-cells are not only selected, but specifically engineered to efficiently destroy the tumour before being transfused to the patient. These therapies include chimeric antigen receptor (CAR)-T-cell therapy as well as T-cell receptor (TCR) engineering.
→ Monoclonal antibodies
Monoclonal antibodies can bind to target cells and mark them for destruction by immune cells or bring them into close proximity with cytotoxic immune cells. New developments also include multispecific antibodies, increasing the specificity for tumour cells and thus reducing adverse effects.
→ Cancer vaccines
Tumor antigens are often neo-antigens not expressed by normal cells or only to a very low extent. Cancer vaccines introduce these antigens to the immune cells and thus strengthen the immune response against the cancer.
→ Immunomodulatory drugs
Several drugs can be used to either stimulate or suppress the immune system. These include for example cytokines like interferons, which enhance the inflammatory reaction of the body. Furthermore, synthetic immunomodulatory drugs have been developed that stimulate the immune system, e.g. thalidomide or lenalidomide.
All these immunotherapies have in common that their specific interaction with the immune cells and/or the tumour cells is crucial for their clinical efficacy. With the switchSENSE® technology you can investigate all necessary interactions to optimize immunotherapies, like receptor-receptor binding, receptor-ligand binding, or antibody-target binding.
→ Characterize and develop therapeutic antibody formats directly on target cells
→ Measure binding kinetics of CAR-T cells and TCR engineered T cells directly on cells to improve therapeutic efficacy
→ Improve checkpoint inhibitors by elucidating their binding kinetics
→ Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action
2021 I Nature Communications (open access)
→ The trimer to monomer transition of Tumor Necrosis Factor-Alpha is a dynamic process that is significantly altered by therapeutic antibodies
2020 I Scientific Reports (open access)
→ Preparation of single- and double-oligonucleotide antibody conjugates and their application for protein analytics
2020 I Scientific Reports (open access)
→ Utilization of Staphylococcal Immune Evasion Protein Sbi as a Novel Vaccine Adjuvant
2019 I frontiers in Immunology (open access)
→ Preclinical Development of a Novel, Orally-Administered Anti-Tumour Necrosis Factor Domain Antibody for the Treatment of Inflammatory Bowel Disease
2018 I Scientific Reports (open access)
→ Messung molekularer Interaktion mit dynamischen Oberflächensensoren
2012 I BIOspektrum
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